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Flexible dosing of Tincture of Opium in the management of opioid withdrawal: pharmacokinetics and pharmacodynamics

By Andrew A Somogyi, Mie Larsen, Reza M Abadi, Jaroon Jittiwutikarn, Robert Ali and Jason M White


WHAT IS ALREADY KNOWN ABOUT THIS SUBJECTIn parts of South-East Asia, Tincture of Opium (TOP) is a culturally acceptable alternative to methadone in the treatment of opioid withdrawal.We have previously shown that TOP has a therapeutic effect when administered to opioid-dependent patients in Northern Thailand.However, before TOP could be used clinically, an evaluation of the dosing regimen had to be undertaken

Topics: Pharmacokinetic Dynamic Relationships
Publisher: Blackwell Science Inc
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Provided by: PubMed Central
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