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Type 1 Diabetes in the BB Rat: A Polygenic Disease

By Robert H. Wallis, KeSheng Wang, Leili Marandi, Eugene Hsieh, Terri Ning, Gary Y.C. Chao, Janice Sarmiento, Andrew D. Paterson and Philippe Poussier
Topics: Original Article
Publisher: American Diabetes Association
OAI identifier: oai:pubmedcentral.nih.gov:2661594
Provided by: PubMed Central
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    Citations

    1. (2005). Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat Genet 37:1317–1319,
    2. (1989). Botstein D: Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121:185–199,
    3. (2007). C: PTPN22 R620W functional variant in type 1 diabetes and autoimmunity related traits. Diabetes 56:522–526,
    4. CM: The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus.
    5. (2005). Cumulative incidence of type 1 diabetes in 10,168 siblings of Finnish young-onset type 1 diabetic patients. Diabetes 54:563–569,
    6. (1999). DL: Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat. Diabetes 48:50–58,
    7. (2007). DL: Rat Models of Type 1 Diabetes: Genetics, Environment and Autoimmunity. Boca
    8. (1994). Doerge RW: Empirical threshold values for quantitative trait mapping. Genetics 138:963–971,
    9. (1999). EP: Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a “universal autoimmunity locus” on rat chromosome 4. Diabetes 48:2138–2144,
    10. (1990). et al.: Prevention of insulindependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A beta-chain or normal I-E alpha-chain.
    11. (2009). from genome-wide analyses of type 1 diabetes.
    12. (2003). GA: R/qtl: QTL mapping in experimental crosses. Bioinformatics 19:889–890,
    13. (2001). Genes of SHR rats protect spontaneously diabetic BB/OK rats from diabetes: lessons from congenic BB.SHR rat strains.
    14. (2005). Genetic analysis of the LEW. 1AR1-iddm rat: an animal model for spontaneous diabetes mellitus. Mamm Genome 16:432– 441,
    15. (2000). Group: Variation and trends in incidence of childhood diabetes in Europe. Lancet 355:873–876,
    16. (2005). Human leukocyte antigen class I B and C loci contribute to type 1 diabetes (T1D) susceptibility and age at T1D onset. Hum Immunol 66:301–313,
    17. (2007). IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5. Genes Immun 8:503–512,
    18. (2007). Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet 39:329–337,
    19. JA: Association between type 1 diabetes age of onset and HLA among sibling pairs.
    20. (2007). JA: Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 450:887–892,
    21. (2008). JA: Metaanalysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
    22. (1992). JF: Age-dependent HLA genetic heterogeneity of type 1 insulin-dependent diabetes mellitus.
    23. (1984). JH: A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus. Diabetes 33:176–183,
    24. (1999). Lernmark A: BB rat diabetes susceptibility and body weight regulation genes colocalize on chromosome 2. Mamm Genome 10:883–887,
    25. (2002). Lernmark A: Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene. Genome Res 12:1029–1039,
    26. (2000). Like AA: Susceptibility to diabetes is widely distributed in normal class IIu haplotype rats. Diabetologia 43:890–898,
    27. (1998). Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat.
    28. (2005). Mordes JP: The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection. Diabetes 54:1233–1237,
    29. (2004). Mustelin T: A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet 36:337–338,
    30. (2002). PJ: High familial risk and genetic susceptibility in early-onset childhood diabetes. Diabetes 51:210–214,
    31. (2004). PK: A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.
    32. (2007). Polychronakos C: A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. Nature 448:591–594,
    33. (2003). Radovic B: Alleles of diabetesresistant BN rats contribute to insulin-dependent type 1 diabetes mellitus.
    34. (1998). RD: Evidence that the age at diagnosis of IDDM is genetically determined. Diabetes Care 21:925–929,
    35. (1992). RD: Polygenic nature of spontaneous diabetes in the rat. Permissive MHC haplotype and presence of the lymphopenic trait of the BB rat are not sufficient to produce susceptibility. Diabetes 41:1617–1623,
    36. (2003). SC: Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.
    37. (1981). Seemayer T: Spontaneous diabetes mellitus syndrome in the rat: I. association with the major histocompatibility complex.
    38. (1983). Seemayer T: Spontaneous diabetes mellitus syndrome in the rat: II. T lymphopenia and its association with clinical disease and pancreatic lymphocytic infiltration.
    39. (1997). Segregation of autoimmune type 1 diabetes in a cross between diabetic BB and brown Norway rats.
    40. (2002). Seino S: Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Nat Genet 31:391–394,
    41. (1995). Serikawa T: Locus on chromosome 18 cosegregates with diabetes in the BB/OK rat subline. Diabetes Metab 21:338–344,
    42. (1993). Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR. Nat Genet 4:305–310,
    43. (2002). The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1. Diabetes 51:1972–1979,
    44. (2002). Thymectomy and radiation-induced type 1 diabetes in nonlymphopenic BB rats. Diabetes 51:2975–2981,
    45. (2004). TW: Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.
    46. (2007). WTCCC: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
    47. (2005). Zeng Z-B:

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