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Functional Characterization of Promoter Variants of the Adiponectin Gene Complemented by Epidemiological Data

By Helmut Laumen, Akuma D. Saningong, Iris M. Heid, Jochen Hess, Christian Herder, Melina Claussnitzer, Jens Baumert, Claudia Lamina, Wolfgang Rathmann, Eva-Maria Sedlmeier, Norman Klopp, Barbara Thorand, H.-Erich Wichmann, Thomas Illig and Hans Hauner
Topics: Original Article
Publisher: American Diabetes Association
OAI identifier: oai:pubmedcentral.nih.gov:2661577
Provided by: PubMed Central

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Citations

  1. (2006). Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.
  2. (2007). Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo.
  3. (2003). Adiponectin gene activation by thiazolidinediones requires PPAR-gamma2, but not C/EBP-alpha: evidence for differential regulation of the aP2 and adiponectin genes. Biochem Biophys Res Comm 308:933–939,
  4. (2005). C: Elevated levels of interleukin-18 predict the development of type 2 diabetes: results from the MONICA/KORA Augsburg Study, 1984–2002. Diabetes 54:2932–2938,
  5. (2005). C: The MONICA Augsburg surveys: basis for prospective cohort studies. Gesundheitswesen 67:13–18,
  6. (2005). C/EBP-alpha regulates human adiponectin gene transcription through an intronic enhancer. Diabetes 54:1744–1754,
  7. (2002). Chuang LM: Synthetic peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients. Diabetes Care 25:376–380,
  8. Eguchi K: Identification of the promoter region required for human adiponectin gene transcription: association with CCAAT/enhancer binding protein-beta and tumor necrosis factor-alpha. Biochem Biophys Res Comm 331:484–490,
  9. (2006). Froguel P: ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity. Diabetes 55:545–550,
  10. (2005). Froguel P: Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity. Diabetologia 48:892–899,
  11. (2002). GA: Score tests for association between traits and haplotypes when linkage phase is ambiguous.
  12. (2000). Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21–q24.
  13. (2000). Giani G: Differential association of adiponectin with cardiovascular risk markers in men and women? The KORA survey
  14. (2006). Haplotypes in the promoter region of the ADIPOQ gene are associated with increased diabetes risk in a German Caucasian population. Horm Metab Res 38:447–451,
  15. Histone H3 lysine 4 dimethylation signals the transcriptional competence of the adiponectin promoter in preadipocytes.
  16. (2006). Hypoadiponectinemia and proinflammatory state: two sides of the same coin?
  17. (2004). Illig T:
  18. (2001). Kadowaki T: The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7:941–946,
  19. (2001). Lodish HF: Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice.
  20. (2003). Matsuzawa Y: Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol 23:85–89,
  21. (2000). Matsuzawa Y: Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 20:1595–1599,
  22. (2006). MH: NFATc4 and ATF3 negatively regulate adiponectin gene expression in 3T3–L1 adipocytes. Diabetes 55:1342–1352,
  23. (2004). Ogihara T: Hypoadiponectinemia is an independent risk factor for hypertension. Hypertension 43:1318–1323,
  24. (2006). Paulweber B: Genetic architecture of the APM1 gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1,727 healthy Caucasians. Diabetes 55:375–384,
  25. (2001). PE: The adipocytesecreted protein Acrp30 enhances hepatic insulin action. Nat Med 7:947– 953,
  26. (2003). Plasma adiponectin and endogenous glucose production in humans. Diabetes Care 26:3315–3319,
  27. (2003). Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism. Diabetes 52:239–243,
  28. (2009). Saruta T: Correlation of the adipocytederived protein adiponectin with insulin resistance index and serum
  29. (2005). Secretory factors from human adipose tissue and their functional role. Proc Nutr Soc 64:163–169,
  30. (2003). Shimomura I: Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes 52:1655–1663,
  31. (1995). Structural organization and chromosomal localization of the mouse collagenase type I gene.
  32. (2008). The HMG-CoA reductase inhibitor rosuvastatin inhibits plasminogen activator inhibitor-1 expression and secretion in human adipocytes. Atherosclerosis 196:565–573,
  33. (2006). The metabolic syndrome and adipocytokines.
  34. (2002). The mode of action of thiazolidinediones.

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