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Gamma-linolenic acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6 glioma model through changes in VEGF, Flt1, ERK1/2, MMP2, cyclin D1, pRb, p53 and p27 protein expression

By Juliano Andreoli Miyake, Marcel Benadiba and Alison Colquhoun
Topics: Research
Publisher: BioMed Central
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Provided by: PubMed Central
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    1. (2005). Baruchel S: A hypoxia-driven vascular endothelial growth factor/Flt1 autocrine loop interacts with hypoxiainducible factor-1alpha through mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 pathway in neuroblastoma. Cancer Res
    2. (2006). Canoll P: Transplanted glioma cells migrate and proliferate on host brain vasculature: a dynamic analysis. Glia
    3. (2007). Cell survival, cell death and cell cycle pathways are interconnected: implications for cancer therapy. Drug Resist Updat
    4. (2008). Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat Rev Cancer
    5. (2009). Colquhoun A: Gamma-linolenic acid alters Ku80, E2F1 and Bax Expression and induces micronucleus formation in C6 glioma cells in vitro. IUBMB Life
    6. (2003). Colquhoun A: Protective role of glucose-6-phosphate dehydrogenase activity in the metabolic response of C6 rat glioma cells to polyunsaturated fatty acid exposure. Glia
    7. (2008). complexes of ibuprofen, aspirin, naproxen and indomethacin non-steroidal anti-inflammatory drugs: Synthesis, characterization and their effects on tumor-cell proliferation. Polyhedron
    8. (2002). Costanzi-Strauss E: Retroviral transfer of the p16INK4a cDNA inhibits C6 glioma formation in Wistar rats. Cancer Cell Int
    9. (2003). Das UN: Gammalinolenic acid therapy of human gliomas. Nutrition
    10. (2006). Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis.
    11. (1998). Effects of saturated and polyunsaturated fatty acids on human tumour cell proliferation. Gen Pharmacol
    12. (2004). EG: Genetic and hypoxic regulation of angiogenesis in gliomas.
    13. (2004). Fontanini G: Angiogenesis in intracranial meningiomas: immunohistochemical and molecular study. Neuropathol Appl Neurobiol
    14. (2007). G: MMP2 role in breast cancer brain metastasis development and its regulation by TIMP2 and ERK1/2. Clin Exp Metastasis
    15. (2002). Gamma-linolenic acid alters the composition of mitochondrial membrane subfractions, decreases outer mitochondrial membrane binding of hexokinase and alters carnitine palmitoyltransferase I properties in the Walker 256 rat tumour. Biochim Biophys Acta
    16. (1998). Gamma-linolenic acid blocks cell cycle progression by regulating phosphorylation of p27kip1 and p57kip2 and their interactions with other cycle regulators in cancer cells.
    17. (2007). Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies. Med Sci Monit
    18. Gas chromatography and mass spectrometry: a practical guide.
    19. (1986). Horrobin DF: Differential killing of human carcinoma cells supplemented with n-3 and n-6 polyunsaturated fatty acids.
    20. (2002). IR: Antitumour and pro-apoptotic actions of highly unsaturated fatty acids in glioma. Prostaglandins Leukot Essent Fatty Acids
    21. (2004). IR: Intracellular oxidation by human glioma cell populations: effect of arachidonic acid. Prostaglandins Leukot Essent Fatty Acids
    22. (2005). JS: Proteases and glioma angiogenesis. Brain Pathol
    23. (2003). Levels of soluble vascular endothelial growth factor (VEGF), receptor 1 in astrocytic tumors and its relation to malignancy, vascularity, and VEGF-A. Clin Cancer Res
    24. (2007). Miyazawa T: Conjugated eicosapentaenoic acid inhibits vascular endothelial growth factor-induced angiogenesis by suppressing the migration of human umbilical vein endothelial cells.
    25. (2004). Palozza P: n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway. Carcinogenesis
    26. (1995). Reddy DR: Local application of gamma-linolenic acid in the treatment of human gliomas. Cancer Lett
    27. (1998). Regulation of tight junction permeability and occludin expression by polyunsaturated fatty acids. Biochem Biophys Res Commun
    28. (2001). RI: Gamma-linolenic acid and eicosapentaenoic acid induce modifications in mitochondrial metabolism, reactive oxygen species generation, lipid peroxidation and apoptosis in Walker 256 rat carcinosarcoma cells. Biochim Biophys Acta
    29. (2001). RI: Modifications in mitochondrial metabolism and ultrastructure and their relationship to tumour growth inhibition by gamma-linolenic acid. Mol Cell Biochem
    30. (2002). Saido T: In vivo glioma growth requires host-derived matrix metalloproteinase 2 for maintenance of angioarchitecture. Pharmacol Res
    31. (1957). Sloane-Stanley GH: A simple method for the isolation and purification of total lipids from animal tissues.
    32. (2008). SY: LC/ESR/MS study of spin trapped carbon-centred radicals formed from in vitro lipoxygenasecatalysed peroxidation of gamma-linolenic acid. Free Radic Res
    33. (2003). SY: Platelet-derived growth factor-B enhances glioma angiogenesis by stimulating vascular endothelial growth factor expression in tumor endothelia and by promoting pericyte recruitment.
    34. (2004). Vascular endothelial growth factor as a target for anticancer therapy. Oncologist
    35. (2006). Vayssière JL: p53 and Retinoblastoma protein (pRb):a complex network of interactions. Apoptosis
    36. (1999). Whittle IR: Dynamics of reactive oxygen intermediate production in human glioma: n-6. Essential fatty acid effects.

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