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Competitive repair pathways in immunoglobulin gene hypermutation

By Claude-Agnès Reynaud, Frédéric Delbos, Ahmad Faili, Quentin Guéranger, Said Aoufouchi and Jean-Claude Weill


This review focuses on the contribution of translesion DNA polymerases to immunoglobulin gene hypermutation, in particular on the roles of DNA polymerase eta (Polη) in the generation of mutations at A/T bases from the initial cytosine-targeted activation-induced cytidine deaminase (AID)-mediated deamination event, and of Polκ, an enzyme of the same polymerase family, used as a substitute when Polη is absent. The proposition that the UNG uracil glycosylase and the MSH2–MSH6 mismatch recognition complex are two competitive rather than alternative pathways in the processing of uracils generated by AID is further discussed

Topics: Review
Publisher: The Royal Society
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Provided by: PubMed Central
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