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Stability of succinylcholine solutions stored at room temperature studied by nuclear magnetic resonance spectroscopy

By Frederic Adnet, Laurence Le Moyec, Charles E Smith, Michel Galinski, Patricia Jabre and Frederic Lapostolle

Abstract

The effect of storage temperature on the stability of two succinylcholine chloride solutions (20 and 50 mg/ml) was evaluated. Molecular composition was analysed using nuclear magnetic resonance spectroscopy. At room temperature, the degradation rate constant was 1.2%/month for the 20 mg/ml solution and 2.1%/month for the 50 mg/ml solution. The corresponding monthly degradation rates for the two solutions were 0.18% and 0.30% when stored at 4°C, and 5.4% and 8.1% when stored at 37°C. If a 10% loss of potency is considered acceptable, then the 20 and 50 mg/ml succinylcholine solutions can be stored in emergency resuscitation carts at room temperature for 8.3 and 4.8 months, respectively

Topics: Original Article
Publisher: BMJ Group
OAI identifier: oai:pubmedcentral.nih.gov:2660020
Provided by: PubMed Central
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