Vitamin D receptor gene polymorphism and 25 hydroxy vitamin D levels in Egyptian patients with pulmonary tuberculosis

Abstract

AbstractBackgroundVitamin D is a potent immunomodulator of innate immune responses, and its deficiency was implicated in the activation of tuberculosis (TB). The effects of vitamin D are exerted by the interaction with the vitamin D receptor (VDR) and may be influenced by polymorphisms in the VDR gene.MethodsWe conducted a case–control study to identify 25(OH) D levels and FOK1 polymorphism of the VDR gene in a group of newly diagnosed pulmonary TB patients and compared to the findings in a group of healthy controls.ResultsObtained results revealed that 25(OH) D levels were significantly lower in the patients than in the controls (P<0.0001), and the prevalence of vitamin D insufficiency was 72.5% in TB patients. The frequencies of FokI genotypes determined from TB patients were 30% for FF , 50% for Ff and 20% for ff, while in controls, the frequency of FF, Ff and ff were present in a percentage of; 40%, 40% and 20%, respectively. There was no significant association between the genotype groups, TB patient and normal control, for FokI polymorphism (P>0.05). Also, no association between VDR genotype and 25(OH) D levels was found.ConclusionFokI polymorphisms in the VDR gene do not appear to be responsible for host susceptibility to human tuberculosis in the Egyptian population. However, vitamin D deficiency may be a cause of the susceptibility to tuberculosis