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Exploring and dissecting genome-wide gene expression responses of Penicillium chrysogenum to phenylacetic acid consumption and penicillinG production

By Diana M Harris, Zita A van der Krogt, Paul Klaassen, Leonie M Raamsdonk, Susanne Hage, Marco A van den Berg, Roel AL Bovenberg, Jack T Pronk and Jean-Marc Daran
Topics: Research Article
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:2657799
Provided by: PubMed Central

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Citations

  1. (2006). 8 kb DNA region amplified in tandem repeats containing the penicillin gene cluster in Penicillium chrysogenum. Fungal Genet Biol
  2. (2006). AD: Relationships between inhibitory activity against a cancer cell line panel, profiles of plants collected, and compound classes isolated in an anticancer drug discovery project. Chem Biodivers
  3. (1999). AJM: Sulfate transport in Penicillium chrysogenum : Cloning and characterization of the sutA and sutB genes.
  4. (2004). Analysis of gene expression in Escherichia coli in response to changes of growth-limiting nutrient in chemostat cultures. Appl Environ Microbiol
  5. (2000). Application of metabolic flux analysis for the identification of metabolic bottlenecks in the biosynthesis of penicillin-G. Biotechnol Bioeng
  6. (1990). Beta-lactam antibiotic biosynthetic genes have been conserved in clusters in prokaryotes and eukaryotes.
  7. (1993). Biochemical characterization and molecular genetics of nine mutants of Penicillium chrysogenum impaired in penicillin biosynthesis.
  8. (2007). Bovenberg RA: Functional characterization of the penicillin biosynthetic gene cluster of Penicillium chrysogenum Wisconsin54-1255. Fungal Genet Biol
  9. (2008). Bovenberg RAL: Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum. Nat Biotechnol
  10. (2007). Cytosolic NADPH metabolism in penicillin-G producing and non-producing chemostat cultures of Penicillium chrysogenum. Metab Eng
  11. (2006). Daran JM: A new physiological role for Pdr12p in Saccharomyces cerevisiae: export of aromatic and branched-chain organic acids produced in amino acid catabolism. FEMS Yeast Res
  12. (2007). Daran JM: Correlation between transcript profiles and fitness of deletion mutants in anaerobic chemostat cultures of Saccharomyces cerevisiae. Microbiology-Sgm
  13. (2009). Daran JM: Engineering of Penicillium chrysogenum for fermentative production of a novel carbamoylated cephem antibiotic precursor. Metab Eng
  14. (2007). de Vroom E, Vollinga RCR: Cephem compound. PCT/NL2004/ 000367(WO 2004/106347)
  15. (2000). De Waard MA: The role of ABC transporters from Aspergillus nidulans in protection against cytotoxic agents and in antibiotic production. Mol Gen Genet
  16. (1992). Demain AL: ACV Synthetase. Crit Rev Biotechnol
  17. (1976). Demain AL: Conversion of penicillin N to cephalosporin(S) by cell-free-extracts of Cephalosporium acremonium. Biochem Biophys Res Comm
  18. (1984). Emborg C: Conversion of Cephalosporin-C into 7-phenoxy-acetamido-cephalosporanic acid by acyltransferase of mutants of Penicillium chrysogenum. Biotechnol Lett
  19. (1999). Fernández-Cañón JM: Disruption of phacA, an Aspergillus nidulans gene encoding a novel cytochrome P450 monooxygenase catalyzing phenylacetate 2-hydroxylation, results in penicillin overproduction.
  20. (2007). Fernández-Cañón JM: Novel phacB-encoded cytochrome P450 monooxygenase from Aspergillus nidulans with 3-hydroxyphenylacetate 6-hydroxylase and 3,4-dihydroxyphenylacetate 6-hydroxylase activities. Eukayot Cell
  21. (1994). Fitting a mixture model by expectation maximization to discover motifs in biopolymers.
  22. (1999). Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science
  23. (2002). Functional profiling of the Saccharomyces cerevisiae genome. Nature
  24. (1997). G: Analysis of a commercially improved Penicillium chrysogenum strain series: involvement of recombinogenic regions in amplification and deletion of the penicillin biosynthesis gene cluster.
  25. (1999). Gene organization and plasticity of the beta-lactam genes in different filamentous fungi. Antonie Van Leeuwenhoek
  26. Genome sequence of Aspergillus
  27. Genome sequence of Trichoderma
  28. (2005). Genome sequencing and analysis of Aspergillus oryzae.
  29. Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS
  30. (2005). Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature
  31. (2001). Heijnen JJ: Energetics of growth and penicillin production in a high-producing strain of Penicillium chrysogenum. Biotechnol Bioeng
  32. (1993). Hohn TM: Aristolochene Synthase – Isolation, characterization, and bacterial expression of a sesquiterpenoid biosynthetic gene (Ari1) from Penicillium roqueforti.
  33. (1986). Ingolia TD: Cloning and expression of the isopenicillin N synthetase gene from Penicillium chrysogenum. Gene
  34. (2007). Isolation and structure elucidation by LC-MS-SPE/ NMR: PR toxin – and cuspidatol-related eremophilane sesquiterpenes from Penicillium roqueforti.
  35. (2006). JF: Amplification and disruption of the phenylacetyl-CoA ligase gene of Penicillium chrysogenum encoding an aryl-capping enzyme that supplies phenylacetic acid to the isopenicillin Nacyltransferase. Biochem J
  36. (1989). JF: Cloning and characterization of the acyl-coenzyme A: 6-aminopenicillanic-acid-acyltransferase gene of Penicillium chrysogenum. Gene
  37. (2001). JL: Structural and phylogenetic analysis of the gamma-actin encoding gene from the penicillin-producing fungus Penicillium chrysogenum. Curr Microbiol
  38. (2005). JW: Fungal secondary metabolism – from biochemistry to genomics. Nat Rev Microbiol
  39. (2001). Keasling JD: The in vivo synthesis of plant sesquiterpenes by Escherichia coli. Biotechnol Bioeng
  40. (2002). Koekman BP: Fermentative production of valuable compounds on an industrial scale using chemically defined media.
  41. (1995). Leibach FH: Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization.
  42. (1989). Libbenga KR: Growth of a Catharanthus roseus cell-suspension culture in a modified chemostat under glucose-limiting conditions. Appl Microbiol Biotechnol
  43. (1989). Luengo JM: Uptake of phenylacetic acid by Penicillium chrysogenum Wis54-1255: a critical regulatory point in benzylpenicillin biosynthesis.
  44. (2007). Martín JF: Deacetylcephalosporin C production in Penicillium chrysogenum by expression of the Isopenicillin N epimerization, ring expansion, and acetylation Genes. Chem Biol
  45. (1987). Martín JF: High-frequency transformation of Penicillium chrysogenum. Bio-Technology
  46. (1989). Martín JF: Large amplification of a 35-kb DNA fragment carrying two penicillin biosynthetic genes in high penicillin producing strains of Penicillium chrysogenum. Curr Genet
  47. (1996). Martín JF: Mutants blocked in penicillin biosynthesis show a deletion of the entire penicillin gene cluster at a specific site within a conserved hexanucleotide sequence. Appl Microbiol Biotechnol
  48. (1990). Martín JF: The cluster of penicillin biosynthetic genes. Identification and characterization of the pcbAB gene encoding the alpha-aminoadipyl-cysteinyl-valine synthetase and linkage to the pcbC and penDE genes.
  49. (1989). Martín JF: Two genes involved in penicillin biosynthesis are linked in a 5.1 kb SalI fragment in the genome of Penicillium chrysogenum.
  50. (2009). MD: The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon,BMC Genomics
  51. (2003). Metabolic engineering of beta-lactam production. Metab Eng
  52. (2004). Mewes HW: The FunCat, a functional annotation scheme for systematic classification of proteins from whole genomes. Nucl Acids Res
  53. (2004). Miñambres B: The homogentisate pathway: a central catabolic pathway involved in the degradation of L-phenylalanine, L-tyrosine, and 3-hydroxyphenylacetate in Pseudomonas putida.
  54. (1998). Modelling of the protonophoric uncoupling by phenoxyacetic acid of the plasma membrane potential of Penicillium chrysogenum. Biotechnol Bioeng
  55. (2007). Nat Biotechnol
  56. (1953). Numerof P: Biosynthesis of penicillin. I. Role of phenylacetic acid. Science
  57. (1929). On the antibacterial action of cultures of a Penicillium, with special reference to their use in the isolation of B. influenza. Exp Pathol
  58. (2007). Paszewski A: Sulfate transport in Aspergillus nidulans : A novel gene encoding alternative sulfate transporter. Fungal Genet Biol
  59. (1995). Penalva MA: Molecular characterization of a gene encoding a homogentisate dioxygenase from Aspergillus nidulans and identification of its human and plant homologues.
  60. (2008). Pronk JT: Chemostat-Based Micro-Array Analysis in Baker's Yeast. Adv Microb Physiol
  61. (2006). Pronk JT: Enzymic analysis of NADPH metabolism in Penicillium chrysogenum : presence of a mitochondrial NADPH dehydrogenase in beta-lactam-producing cultures. Metab Eng
  62. (1999). Pronk JT: Genome-wide transcriptional analysis of aerobic and anaerobic chemostat cultures of Saccharomyces cerevisiae.
  63. (2002). Pronk JT: Reproducibility of oligonucleotide microarray transcriptome analyses. An interlaboratory comparison using chemostat cultures of Saccharomyces cerevisiae.
  64. (2004). Pronk JT: Role of transcriptional regulation in controlling fluxes in central carbon metabolism of Saccharomyces cerevisiae. A chemostat culture study.
  65. (2005). Pronk JT: Two-dimensional transcriptome analysis in chemostat cultures – Combinatorial effects of oxygen availability and macronutrient limitation in Saccharomyces cerevisiae.
  66. (1995). Protein burden in Zymomonas mobilis – Negative flux and growth-control due to overproduction of glycolytic enzymes. Microbiology-Sgm
  67. (2001). Reduced function of a phenylacetate-oxidizing cytochrome P450 caused strong genetic improvement in early phylogeny of penicillin-producing strains.
  68. (1995). Reeves CD: Production of cephalosporin intermediates by feeding adipic acid to recombinant Penicillium chrysogenum strains expressing ring expansion activity. Bio-Technology
  69. (2005). RK: Genome-wide transcriptional response of chemostat-cultured to zinc.
  70. (2004). SE: WebLogo: a sequence logo generator. Genome Res
  71. (2005). Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae. Nature
  72. (2001). Significance analysis of microarrays applied to the ionizing radiation response.
  73. (1997). T: Characterization of alpha-ketoglutarate-dependent taurine dioxygenase from Escherichia coli.
  74. (2000). The ABC transporter AtrB from Aspergillus nidulans mediates resistance to all major classes of fungicides and some natural toxic compounds.
  75. (2003). The genome sequence of the filamentous fungus Neurospora crassa. Nature
  76. (1998). The optimization of penicillin biosynthesis in fungi. Trends Biotechnol
  77. (1986). The Panlabs penicillin strain improvement programme. In Overproduction of microbial metabolites Edited by: Vanek Z, Hostálek Z.
  78. (1995). The penicillin gene cluster is amplified in tandem repeats linked by conserved hexanucleotide sequences. Proc Natl Acad Sci USA
  79. (1955). The production and selection of a family of strains in Penicillium chrysogenum. Mycologia
  80. Transcriptional and bioinformatic analysis of the
  81. (2006). Transcriptional monitoring of steady state and effects of anaerobic phases in chemostat cultures of the filamentous fungus Trichoderma reesei.
  82. (1988). transition from glucose limitation to glucose excess. Yeast
  83. (1998). Uptake of phenylacetic acid by two strains of Penicillium chrysogenum. Biotechnol Bioeng
  84. (2001). Wanders RJ: Identification of a peroxisomal ATP carrier required for medium-chain fatty acid beta-oxidation and normal peroxisome proliferation in Saccharomyces cerevisiae. Mol Cell Biol
  85. (2007). Wessels LFA: Exploiting combinatorial cultivation conditions to infer transcriptional regulation.
  86. (2005). Why did the Fleming strain fail in penicillin industry? Fungal Genet Biol
  87. (1999). WN: Compartmentalization and transport in beta-lactam antibiotic biosynthesis by filamentous fungi. Antonie Van Leeuwenhoek
  88. (1995). WN: Penicillium chrysogenum takes up the Penicillin G precursor phenylacetic acid by passive diffusion. Appl Environ Microbiol

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