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Disease candidate gene identification and prioritization using protein interaction networks

By Jing Chen, Bruce J Aronow and Anil G Jegga
Topics: Research Article
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:2657789
Provided by: PubMed Central

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Citations

  1. (2003). A Bayesian networks approach for predicting protein-protein interactions from genomic data. Science
  2. (2005). A human protein-protein interaction network: a resource for annotating the proteome. Cell
  3. (2004). A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. Mol Cell
  4. (1977). A set of measures of centrality based on betweenness. Sociometry
  5. (2004). A: Structure and evolution of protein interaction networks: a statistical model for link dynamics and gene duplications.
  6. (2007). AG: Improved human disease candidate gene prioritization using mouse phenotype.
  7. Algorithms for estimating relative importance in networks.
  8. (2002). AN: Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy. Proc Natl Acad Sci USA
  9. (1999). Authoritative sources in a hyperlinked environment.
  10. (2007). Bouwmeester T: Human protein-protein interaction networks and the value for drug discovery. Drug Discov Today
  11. (2005). BS: Speeding disease gene discovery by sequence based candidate prioritization.
  12. (2006). BS: SUSPECTS: enabling fast and effective prioritization of positional candidates. Bioinformatics
  13. (1978). Centrality in social networks conceptual clarification. Social Networks
  14. (2003). Clutterbuck DR, Semple CA: POCUS: mining genomic sequence annotation to predict disease genes. Genome Biol
  15. (2004). Combining biological networks to predict genetic interactions. Proc Natl Acad Sci USA
  16. (2006). Combining functional and topological properties to identify core modules in protein interaction networks. Proteins
  17. (2006). Computational disease gene identification: a concert of methods prioritizes type 2 diabetes and obesity candidate genes. Nucleic Acids Res
  18. (2008). Computing topological parameters of biological networks.
  19. (2003). Danieli GA: Disease genes and intracellular protein networks. Physiol Genomics
  20. (2006). Discovering disease-genes by topological features in human protein-protein interaction network. Bioinformatics
  21. (2007). Discovery of protein interaction networks shared by diseases. Pac Symp Biocomput
  22. (2003). Eckner R: Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5. Embo J
  23. (1999). Emergence of scaling in random networks.
  24. (2002). ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med
  25. (2005). et al.: Towards a proteome-scale map of the human protein-protein interaction network. Nature
  26. (2008). Exploiting the proteome to improve the genome-wide genetic analysis of epistasis in common human diseases. Hum Genet
  27. (2006). Exploration of biological network centralities with CentiBiN.
  28. (2001). Fell DA: The small world inside large metabolic networks.
  29. (2006). Gene prioritization through genomic data fusion. Nat Biotechnol
  30. (2001). Gomez SM: Birth of scale-free molecular networks and the number of distinct DNA and protein domains per genome. Bioinformatics
  31. (2006). HG: Predicting disease genes using protein-protein interactions.
  32. (2003). Hogue CW: BIND: the Biomolecular Interaction Network Database. Nucleic Acids Res
  33. Human protein reference database as a discovery resource for proteomics.
  34. (2003). Ideker T: Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res
  35. (2006). Ideker T: Modeling cellular machinery through biological network comparison. Nat Biotechnol
  36. (2005). Interactome-transcriptome analysis reveals the high centrality of genes differentially expressed in lung cancer tissues. Bioinformatics
  37. (2003). Levanon EY: Preferential attachment in the protein network evolution. Phys Rev Lett
  38. (2007). Ma'ayan A: Genes2Networks: connecting lists of gene symbols using mammalian protein interactions databases.
  39. (2007). Mining gene-disease relationships from biomedical literature: weighting protein-protein interactions and connectivity measures. Pac Symp Biocomput
  40. (2005). Mutation in myosin heavy chain 6 causes atrial septal defect. Nat Genet
  41. Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders.
  42. (2008). PN: Walking the interactome for prioritization of candidate disease genes.
  43. (2007). Protein interactions and disease: computational approaches to uncover the etiology of diseases. Brief Bioinform
  44. (2005). RB: Systematic discovery of new recognition peptides mediating protein interaction networks. PLoS Biol
  45. (2001). S: Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator. Nat Genet
  46. (2008). S: Network-based global inference of human disease genes. Mol Syst Biol
  47. (2004). SA: The genetic association database. Nat Genet
  48. (2001). T: The pagerank citation ranking: Bringing order to the web.
  49. (2008). The BioGRID Interaction Database:
  50. (1966). The centrality index of a graph. Psychometrika
  51. (2007). The commonality of protein interaction networks determined in neurodegenerative disorders (NDDs). Bioinformatics
  52. (2005). Whole-proteome prediction of protein function via graph-theoretic analysis of interaction maps. Bioinformatics
  53. (2006). Wouters MA: Analysis of protein sequence and interaction data for candidate disease gene prediction. Nucleic Acids Res
  54. (1999). Yamamura K: Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: implications for a dominant-negative mechanism. Hum Mol Genet

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