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Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles

By Louis-S. Bouchard, M. Sabieh Anwar, Gang L. Liu, Byron Hann, Z. Harry Xie, Joe W. Gray, Xueding Wang, Alexander Pines and Fanqing Frank Chen

Abstract

Multimodality imaging based on complementary detection principles has broad clinical applications and promises to improve the accuracy of medical diagnosis. This means that a tracer particle advantageously incorporates multiple functionalities into a single delivery vehicle. In the present work, we explore a unique combination of MRI and photoacoustic tomography (PAT) to detect picomolar concentrations of nanoparticles. The nanoconstruct consists of ferromagnetic (Co) particles coated with gold (Au) for biocompatibility and a unique shape that enables optical absorption over a broad range of frequencies. The end result is a dual-modality probe useful for the detection of trace amounts of nanoparticles in biological tissues, in which MRI provides volume detection, whereas PAT performs edge detection

Topics: Physical Sciences
Publisher: National Academy of Sciences
OAI identifier: oai:pubmedcentral.nih.gov:2657430
Provided by: PubMed Central
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