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Differential expression of Caveolin-1 in hepatocellular carcinoma: correlation with differentiation state, motility and invasion

By Murat Cokakli, Esra Erdal, Deniz Nart, Funda Yilmaz, Ozgul Sagol, Murat Kilic, Sedat Karademir and Nese Atabey
Topics: Research Article
Publisher: BioMed Central
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Provided by: PubMed Central

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  2. (2006). A: Caveolin-1 is essential for liver regeneration. Science
  3. (2003). Acquired tolerance of hepatocellular carcinoma cells to selenium deficiency: a selective survival mechanism. Cancer Res
  4. (2001). Antonaci S: Human hepatocellular carcinoma (HCC) cells require both a3b1 integrin and matrix metalloproteinases activity for migration and invasion. Lab Invest
  5. (2006). Antonaci S: Novel concepts in hepatocellular carcinoma: from molecular research to clinical practice.
  6. (2007). Asahara T: Clinopathologic features of poorly differentiated hepatocellular carcinoma. J Surg Oncol
  7. (2006). Caveolin-1 up-regulates CD147 glycosylation and the invasive capability of murine hepatocarcinoma cell lines.
  8. (2003). cDNA microarray analysis of macroregenerative and dysplastic nodules in end-stage hepatitis C virus-induced cirrhosis.
  9. (2002). Chem
  10. (2007). Correlation analysis of liver tumor associated genes with liver regeneration.
  11. (2005). DeMatteo RP: Molecular mechanisms in hepatocellular carcinoma development. Best Pract Res Clin Gastroenterol
  12. (2003). Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion. Cancer Cell
  13. (2006). Dysregulation of growth factor signaling in human hepatocellular carcinoma. Oncogene
  14. (2007). Ebert MP: Differential expression and function of caveolin-1 in human gastric cancer progression. Cancer Res
  15. (2003). Elevated expression of caveolin-1 at protein and mRNA level in human cirrhotic liver: relation with nitric oxide.
  16. (2006). Epithelial growth factor-induced phosphorylation of caveolin 1 at tyrosine 14 stimulates caveolae formation in epithelial cells.
  17. (2008). HP: Radiationinduced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK. Mol Cancer
  18. (2008). Insulin-like growth factor-I activation of Akt survival cascade in neuronal cells requires the presence of its cognate receptor in caveolae. Exp Cell Res
  19. (1994). LH: Histological typing of tumors of the liver. WHO international histological classification of tumors.
  20. (2004). Liver regeneration: from myth to mechanism. Nat Rev Mol Cell Biol
  21. (1995). MP: Reduction of caveolin and caveolae in oncogenically transformed cells.
  22. (2006). MP: Stromal and epithelial caveolin-1 both confer a protective effect against mammary hyperplasia and tumorigenesis: caveolin-1 antagonizes cyclin D1 function in mammary epithelial cells.
  23. (2006). Ng IO: Interaction of deleted in liver cancer 1 with tensin-2 in caveolae and implications in tumor suppression. Cancer Res
  24. (2006). O: Methylation status of genes upregulated by demethylating agent 5-aza-2'-deoxycytidine in hepatocellular carcinoma. Oncology
  25. (1999). R o l l s B , H a n c o c k M , P a r t o n R G : Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains. Nature Cell Biol
  26. RGW: Multiple functions of caveolin-
  27. (2002). SM: Up-regulated caveolin-1 accentuates the metastasis capability of lung adenocarcinoma by inducing filopodia formation.
  28. (2007). ST: Atypical localization of membrane type 1 matrix metalloproteinase in the nucleus is associated with aggressive features of hepatocellular carcinoma. Mol Carcinog
  29. (2006). SW: Identification and validation of oncogenes in liver cancer using an integrative oncogenomics approach. Cell
  30. (2008). Tanabe KK: Epithelial-to-mesenchymal transition and integrinlinked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells. Cancer Res
  31. (2007). TC: Correlative evidence that prostate cancer cellderived caveolin-1 mediates angiogenesis. Hum Pathol
  32. (2006). The genetic and environmental basis of hepatocellular carcinoma. Discov Med
  33. (2007). The importance of IP3-kinase signaling in hepatocellular carcinoma.
  34. (2007). The multiple faces of caveolae.
  35. (2001). Tzakis AG: Impact of histological grade of hepatocellular carcinoma on the outcome of liver transplantation. Arch Surg

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