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Discovery of Herpes B Virus-Encoded MicroRNAs▿

By Michael I. Besecker, Mallory E. Harden, Guanglin Li, Xiu-Jie Wang and Anthony Griffiths

Abstract

Herpes B virus (BV) naturally infects macaque monkeys and is a close relative of herpes simplex virus. BV can zoonotically infect humans to cause a rapidly ascending encephalitis with ∼80% mortality. Therefore, BV is a serious danger to those who come into contact with these monkeys or their tissues and cells. MicroRNAs are regulators of gene expression, and there have been reports of virus-encoded microRNAs. We hypothesize that BV-encoded microRNAs are important for the regulation of viral and cellular genes. Herein, we report the discovery of three herpes B virus-encoded microRNAs

Topics: Genome Replication and Regulation of Viral Gene Expression
Publisher: American Society for Microbiology (ASM)
OAI identifier: oai:pubmedcentral.nih.gov:2655578
Provided by: PubMed Central
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