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Tailoring the P450 Monooxygenase Gene for FR-008/Candicidin Biosynthesis▿ †

By Shi Chen, Xiangzhao Mao, Yaling Shen, Yongjun Zhou, Jialiang Li, Lianrong Wang, Xinyi Tao, Liang Yang, Yuxiao Wang, Xiufen Zhou, Zixin Deng and Dongzhi Wei


Tailoring steps are often important for the activity of mature antibiotics. Here, we report that novel decarboxylated FR-008/candicidin derivatives were obtained from the P450 monooxygenase gene fscP mutant of Streptomyces sp. strain FR-008. The toxicity of decarboxylated FR-008/candicidin derivatives has been shown to be greatly reduced compared to that of wild-type FR-008/candicidin

Topics: Genetics and Molecular Biology
Publisher: American Society for Microbiology (ASM)
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Provided by: PubMed Central
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