Skip to main content
Article thumbnail
Location of Repository

Fine-mapping QTL for mastitis resistance on BTA9 in three Nordic red cattle breeds

By G Sahana, M S Lund, L Andersson-Eklund, N Hastings, A Fernandez, T Iso-Touru, B Thomsen, S Viitala, P Sørensen, J L Williams and J Vilkki

Abstract

A QTL affecting clinical mastitis and/or somatic cell score (SCS) has been reported previously on chromosome 9 from studies in 16 families from the Swedish Red and White (SRB), Finnish Ayrshire (FA) and Danish Red (DR) breeds. In order to refine the QTL location, 67 markers were genotyped over the whole chromosome in the 16 original families and 18 additional half-sib families. This enabled linkage disequilibrium information to be used in the analysis. Data were analysed by an approach that combines information from linkage and linkage disequilibrium, which allowed the QTL affecting clinical mastitis to be mapped to a small interval (<1 cM) between the markers BM4208 and INRA084. This QTL showed a pleiotropic effect on SCS in the DR and SRB breeds. Haplotypes associated with variations in mastitis resistance were identified. The haplotypes were predictive in the general population and can be used in marker-assisted selection. Pleiotropic effects of the mastitis QTL were studied for three milk production traits and eight udder conformation traits. This QTL was also associated with yield traits in DR but not in FA or SRB. No QTL were found for udder conformation traits on chromosome 9

Topics: Articles
Publisher: Blackwell Publishing Ltd
OAI identifier: oai:pubmedcentral.nih.gov:2655356
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Citations

    1. (2003). A comparison of bivariate and univariate QTL mapping in livestock populations.
    2. (2001). A quick method for computing approximate threshold for quantitative trait loci detection.
    3. (1997). Biological basis for selection on udder health traits.
    4. (2004). Commercial application of marker- and geneassisted selection in livestock: strategies and lessons.
    5. (1995). Covariance between relatives for a marked quantitative trait locus.
    6. (2003). Detection of genes influencing economic traits in three French dairy cattle breeds.
    7. (2006). DMU – A Package for Analyzing Multivariate Mixed Models.
    8. (1999). Estimation of genetic and phenotypic parameters for clinical mastitis, somatic cell production deviance and protein yield in dairy cattle using Gibbs sampling.
    9. (2002). Fine mapping of a quantitative trait locus for twinning rate using combined linkage and linkage disequilibrium mapping.
    10. (2000). Fine mapping of quantitative trait loci using linkage disequilibria with closely linked marker loci.
    11. (2006). Genetic associations between clinical mastitis and somatic cell score in early first-lactation cows.
    12. (2004). Genetic parameters for clinical mastitis, somatic cell score and production in the first three lactations of Swedish Holstein cows.
    13. (1999). Genetic parameters for clinical mastitis, somatic cell score, production, udder type traits and milking ease in first lactation Holsteins.
    14. (2002). Genetic parameters of dairy character, protein yield, clinical mastitis and other diseases in Danish Holstein cattle.
    15. (1998). Genetics and Analysis of Quantitative traits. Sinauer Associates,
    16. (2003). Genetics of resistance to mastitis in dairy cattle.
    17. (1998). Incidence of clinical mastitis in dairy herds in England.
    18. (2007). Joint analysis of five chromosomes affecting clinical mastitis and somatic cell score in three Nordic QTL experiments.
    19. (2006). Joint Nordic test day model: variance components.
    20. (1995). Mapping quantitative trait loci controlling milk production in dairy cattle by exploiting progeny testing.
    21. (1994). Modeling the impact of mastitis on milk production by dairy cows.
    22. (1997). Multiple marker mapping of quantitative trait loci of Finnish dairy cattle by regression.
    23. (1995). Multiple trait analysis of genetic mapping for quantitative trait loci.
    24. (2003). Multitrait fine mapping of quantitative trait loci using combined linkage disequilibria and linkage analysis.
    25. (2000). Multitrait least squares for quantitative trait loci detection.
    26. (2002). Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition.
    27. (1990). Power of daughter and granddaughter designs for determining linkage between marker loci and quantitative trait loci in dairy cattle.
    28. (2001). Prediction of identity by descent probabilities from marker-haplotypes.
    29. (2004). Quantitative trait loci affecting health traits in Swedish dairy cattle.
    30. (1997). Residual maximum likelihood estimation of (co)variance components in multivariate mixed linear models using average information.
    31. (2000). Selection for mastitis in dairy cattle: a review with focus on the situation of the Nordic countries.
    32. (2000). Testing for the presence of previously identified QTL for milk production traits in new populations.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.