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Preliminary fMRI findings in experimentally sleep-restricted adolescents engaged in a working memory task

By Dean W Beebe, Mark W DiFrancesco, Sarah J Tlustos, Kelly A McNally and Scott K Holland

Abstract

Here we report preliminary findings from a small-sample functional magnetic resonance imaging (fMRI) study of healthy adolescents who completed a working memory task in the context of a chronic sleep restriction experiment. Findings were consistent with those previously obtained on acutely sleep-deprived adults. Our data suggest that, when asked to maintain attention and burdened by chronic sleep restriction, the adolescent brain responds via compensatory mechanisms that accentuate the typical activation patterns of attention-relevant brain regions. Specifically, it appeared that regions that are normally active during an attention-demanding working memory task in the well-rested brain became even more active to maintain performance after chronic sleep restriction. In contrast, regions in which activity is normally suppressed during such a task in the well-rested brain showed even greater suppression to maintain performance after chronic sleep restriction. Although limited by the small sample, study results provide important evidence of feasibility, as well as guidance for future research into the functional neurological effects of chronic sleep restriction in general, the effects of sleep restriction in children and adolescents, and the neuroscience of attention and its disorders in children

Topics: Short Paper
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:2654567
Provided by: PubMed Central
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    Citations

    1. (2002). AC: A general statistical analysis for fMRI data. NeuroImage
    2. (2002). Adolescent sleep patterns: Biological, social, and psychological influences Cambridge, UK:
    3. (2004). An event-related fMRI study of the neurobehavioral impact of sleep deprivation on performance of a delayedmatch-to-sample task. Brain Res Cogn Brain Res
    4. (2008). BP: Physiological arousal and attention during a week of continuous sleep restriction. Physiol Behav
    5. (1998). Carskadon MA: Sleep schedules and daytime functioning in adolescents. Child Dev
    6. (2007). Castellanos FX: Spontaneous attentional fluctuations in impaired states and pathological conditions: a neurobiological hypothesis. Neurosci Biobehav Rev
    7. (2004). Choo WC: Functional imaging of working memory after 24 hr of total sleep deprivation.
    8. (2007). CN: Wandering minds: the default network and stimulusindependent thought. Science
    9. (2006). Committee on Sleep Medicine and Research: Sleep disorders and sleep deprivation: An unmet public health problem
    10. (2006). DF: Functional imaging of working memory following normal sleep and after 24 and 35 h of sleep deprivation: Correlations of fronto-parietal activation with performance. Neuroimage
    11. (2008). Feasibility and behavioral effects of an at-home multi-night sleep restriction protocol for adolescents. Jn Child Psychol Psychiatry
    12. (2005). GG: Compensatory recruitment after sleep deprivation and the relationship with performance. Psychiatry Res
    13. (2001). GG: Increased cerebral response during a divided attention task following sleep deprivation.
    14. (1993). Imaging at high magnetic fields: initial experiences at 4 T. Magn Reson Q
    15. (2000). Imaging cognition II: An empirical review of 275 PET and fMRI studies.
    16. (2004). Increasing task difficulty facilitates the cerebral compensatory response to total sleep deprivation. Sleep
    17. (1999). JC: Sleep deprivation-induced reduction in cortical functional response to serial subtraction. Neuroreport
    18. (1999). KJ: Multisubject fMRI studies and conjunction analyses. NeuroImage
    19. (2006). Kwong K: Modafinil activates cortical and subcortical sites in the sleep-deprived state. Sleep
    20. (1999). L: Brodmann's "Localisation in the cerebral cortex" London:
    21. (2005). MA: Homeostatic sleep regulation in adolescents. Sleep
    22. (2005). MJ: The neural basis of the psychomotor vigilance task. Sleep
    23. (1996). MR imaging contrast in human brain tissue: assessment and optimization at 4 T. Radiology
    24. (2007). MW: Reproducibility of changes in behaviour and fMRI activation associated with sleep deprivation in a working memory task. Sleep
    25. (1993). Peters TM: 3D statistical neuroanatomical models from 305 MRI volumes.
    26. (2005). Raichle ME: The human brain is intrinsically organized into dynamic, anticorrelated functional networks.
    27. (2005). SM: Comorbid ADHD is associated with altered patterns of neuronal activation in adolescents with bipolar disorder performing a simple attention task. Bipolar Disord
    28. Statistical Parametric Mapping
    29. (2006). Woldorff MG: The neural bases of momentary lapses in attention. Nat Neurosci

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