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Beneficial Effects of Cocoa in Perivascular Mato Cells of Cerebral Arterioles in SHR-SP (Izm) Rats

By Takashi Mato, Masanori Kamei, Ryoichi Ito, Makoto Sawano, Koichi Inokuchi, Kazuyuki Nakata, Atsushi Yamaguchi, Tom Kouki, Umehachi Mitsuhashi and Masao Mato


As previously reported, the cerebral arterioles are surrounded by unique perivascular Mato cells. They contain many inclusion bodies rich in hydrolytic enzymes, and have strong uptake capacity. They are thus considered scavenger cells of vascular and neural tissues in steady-state. In this study, employing hypertensive SHR-SP (Izm) rats, the viability of Mato cells was investigated. In hypertensive rats, the capacity for uptake of horse radish peroxidase (HRP) and the activity of acid phosphatase (ACPase) of Mato cells were markedly reduced, and on electron-microscopic examination Mato cells were found to include heterogeneous contents and appeared electron-dense and degenerated. Vascular cells exhibited some signs of pathology. However, in hypertensive rats fed chow containing 0.25% cocoa, the uptake capacity and ACPase activity of Mato cells for HRP were enhanced, and on electron-microscopic examination Mato cells appeared healthy, with mitochondria with nearly normal profiles. Signs of pathology in vascular cells were also decreased. Superoxides may impair Mato cells and vascular cells

Topics: Original Article
Publisher: the Society for Free Radical Research Japan
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Provided by: PubMed Central

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  5. (1996). Involvement of specific macrophage-lineage cells surrounding arterioles in barrier and scavenger function in brain cortex.
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  10. (2007). Study on the Distribution of Collagen Fibers in the Bifurcating Area of Cerebral Arterioles of Wistar Rats.
  11. (1980). Regression of granular pericytes in cerebral fine vessels of rats after administration of vitamin E deficient diet.
  12. (1981). The effect of Vitamin E on aging of granular peritherila cell in cerebral fine vessels of rat.
  13. (2000). Vascular NADH/NADPH oxidase is involved in enhanced superoxide production in spontaneously hypertensive rats.
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  16. (1998). Growth retardation of Mato’s fluorescent granular perithelial (FGP) cells in scavenger receptor knockout (SRKO) mice.
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