Skip to main content
Article thumbnail
Location of Repository

Glutathione-S-transferases in lung and sputum specimens, effects of smoking and COPD severity

By Terttu Harju, Witold Mazur, Heta Merikallio, Ylermi Soini and Vuokko L Kinnula
Topics: Research
Publisher: BioMed Central
OAI identifier:
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles


    1. (2006). Adcock IM: Oxidative stress and redox regulation of lung inflammation in COPD. Eur Respir J
    2. (2002). AJ: Antioxidant gene polymorphisms and susceptibility to a rapid decline in lung function in smokers.
    3. (2007). Baraniuk JN: Protein expression in sputum of smokers and chronic obstructive pulmonary disease patients: a pilot study by CapLC-ESI-Q-TOF. J Proteome Res
    4. (2004). Biswal S: Genetic ablation of Nrf2 enhances susceptibility to cigarette smokeinduced emphysema in mice.
    5. (1997). CA: Frequency of glutathione S-transferase M1 deletion in smokers with emphysema and lung cancer. Hum Exp Toxicol
    6. (2003). Crystal RG: Variability of antioxidant-related gene expression in the airway epithelium of cigarette smokers.
    7. (1994). DJ: Heterogeneous expression and polymorphic genotype of glutathione S-transferases in human lung. Thorax
    8. (2007). Djukanovic R: Expression of genes involved in oxidative stress responses in airway epithelial cells of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med
    9. (2002). EH: beta-Actin and GAPDH housekeeping gene expression in asthmatic airways is variable and not suitable for normalising mRNA levels. Thorax
    10. (2006). Ercan B: The association between polymorphic genotypes of glutathione S-transferases and COPD in the Turkish population. Biochem Genet
    11. (2006). Expression of xenobiotic metabolizing enzymes in different lung compartments of smokers and nonsmokers. Environ Health Perspect
    12. (2005). Focus on antioxidant enzymes and antioxidant strategies in smoking related airway diseases. Thorax
    13. (2002). Hargreave FE: Standardised methodology of sputum induction and processing.
    14. (2005). IR: Glutathione transferases. Annu Rev Pharmacol Toxicol
    15. (2007). Kinnula VL: Glutathione S-transferase omega in the lung and sputum supernatants of COPD patients. Respir Res
    16. (2006). Kinnula VL: Modulation of glutaredoxin in the lung and sputum of cigarette smokers and chronic obstructive pulmonary disease. Respir Res
    17. (2005). Kleeberger SR: Gene expression profiling of NRF2-mediated protection against oxidative injury. Free Radic Biol Med
    18. (2008). Kleeberger SR: Oxidative stress and antioxidants in the pathogenesis of pulmonary fibrosis: a potential role for Nrf2. Antioxid Redox Signal
    19. (2005). MacNee W: Oxidative stress and airway inflammation in severe exacerbations of COPD. Thorax
    20. (1996). MacNee W: Systemic oxidative stress in asthma, COPD, and smokers.
    21. (1997). Peculiarities of the GSTM1 0/ 0 genotype in French heavy smokers with various types of chronic bronchitis. Hum Genet
    22. (2007). Probst-Hensch NM: Glutathione S-transferase genotypes modify lung function decline in the general population: SAPALDIA cohort study. Respir Res
    23. (2007). Reddy SP: Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants.
    24. (1987). RG: Normal alveolar epithelial lining fluid contains high levels of glutathione.
    25. (2006). Sandford AJ: Stability of housekeeping genes in alveolar macrophages from COPD patients. Eur Respir J
    26. (2005). Sekizawa K: Transcription factor Nrf2 plays a pivotal role in protection against elastase-induced pulmonary inflammation and emphysema.
    27. (1991). Serabjit-Singh CJ: The major alpha-class glutathione S-transferases of rabbit lung and liver. Primary sequences, expression, and regulation.
    28. (2002). Tumor necrosis factor-alpha inhibits glutathione S-transferasealpha expression in cultured porcine Sertoli cells.
    29. (2002). VL: Diminished immunoreactivity of gamma-glutamylcysteine synthetase in the airways of smokers' lung.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.