Skip to main content
Article thumbnail
Location of Repository

Inducible expression of beta defensins by human respiratory epithelial cells exposed to Aspergillus fumigatus organisms

By Ludmila Alekseeva, Dominique Huet, Françoise Féménia, Isabelle Mouyna, Mahdia Abdelouahab, Adrien Cagna, Daniel Guerrier, Virginie Tichanné-Seltzer, Armelle Baeza-Squiban, René Chermette, Jean-Paul Latgé and Nadia Berkova
Topics: Research article
Publisher: BioMed Central
OAI identifier:
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles


    1. (2001). A new mathematical model for relative quantification in real-time RT-PCR.
    2. (2001). Aasen AO: Involvement of CD14 and TollLike Receptors in Activation of Human Monocytes by Aspergillus fumigatus Hyphae. Infect Immun
    3. (2005). Aspergillosis in the CLEAR outcomes trial: working toward a real-world clinical perspective. Med Mycol
    4. (2001). Bals : Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction. Cell Tissue Res
    5. (2007). BetaDefensins chemoattract macrophages and mast cells but not lymphocytes and dendritic cells: CCR6 is not involved.
    6. Betadefensins: linking innate and adaptive immunity through dendritic and T cell CCR6.
    7. (2008). Carratelli CR: Modulation of cytokine and beta-defensin 2 expressions in human gingival fibroblasts infected with Chlamydia pneumoniae. Int Immunopharmacol
    8. (2006). Dectin-1 and TL Rs permit macrophages to distinguish between different Aspergillus fumigatus cellular states.
    9. (2005). E: Human β-defensin 2 is expressed and associated with Mycobacterium tuberculosis during infection of human alveolar epithelial cells. Infect Immun
    10. (2000). Epithelial antimicrobial peptides in host defense against infection. Respir Res
    11. (1998). Epithelial antimicrobial peptides: review and significance for oral applications. Crit Rev Oral Biol Med
    12. (2008). Escudier E, Bretagne S: Phagocytosis of Aspergillus fumigatus conidia by primary nasal epithelial cells in vitro.
    13. (1995). Forssmann WG: hBD-1: a novel beta-defensin from human plasma. FEBS Lett
    14. (2005). GD: The beta-glucan receptor dectin-1 recognizes specific morphologies of Aspergillus fumigatus. PLoS Pathog
    15. (1994). Gruenert DC: CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells.
    16. (2007). Hammarström ML: Beta-defensin production by human colonic plasma cells: a new look at plasma cells in ulcerative colitis. Inflamm Bowel Dis
    17. (2005). HF: Interaction of airway epithelial cells (A549) with spores and mycelium of Aspergillus fumigatus.
    18. (2006). Hirvonen MR: Aspergillus fumigatus challenge increases cytokine levels in nasal lavage fluid. Inhal Toxicol
    19. (1997). HR: The role of complement in the pathophysiology of lung diseases.
    20. (1999). Human beta-defensin-2.
    21. (2000). Inducible expression of human beta-defensin 2 by Fusobacterium nucleatum in oral epithelial cells: multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier. Infect Immun
    22. (2004). Interactions of Aspergillus fumigatus with endothelial cells:internalization, injury, and stimulation of tissue factor activity. Blood
    23. Isolation and characterization of human defensin cDNA clones.
    24. (2007). JG: Rapid tissue factor induction by oral streptococci and monocyte-IL-1beta. J Dent Res
    25. (2004). JM: Expression and regulation of novel human beta-defensins in gingival keratinocytes. Oral Microbiol Immunol
    26. (1998). Jr: Production of beta-defensins by human airway epithelia. Proc Natl Acad Sci USA
    27. (2002). JW: Sequencing the Aspergillus fumigatus genome. Lancet Infect Dis
    28. (2003). Kullberg BJ: Aspergillus fumigatus evades immune recognition during germination through loss of toll-like receptor-4-mediated signal transduction.
    29. (2005). L: Immunity to Aspergillus fumigatus: the basis for immunotherapy and vaccination. Med Mycol
    30. (2006). Latge JP: Aspergillus fumigatus conidia inhibit tumour necrosis factor- or staurosporine-induced apoptosis in epithelial cells. Intern Immunol
    31. (2005). Lehrer RI: Widespread expression of betadefensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett
    32. (2004). Mahida YR: Expression and regulation of antimicrobial peptides in the gastrointestinal tract.
    33. (2002). Marano F: Effects of retinoic acid receptor-selective agonists on human nasal epithelial cell differentiation.
    34. (2002). McCray TL: Discovery of five conserved betadefensin gene clusters using a computational search strategy. Proc Natl Acad Sci USA
    35. (2003). MM: Aspergillus fumigatus conidia survive and germinate in acidic organelles of A549 epithelial cells.
    36. (2007). Modulation of the Complement System by Human β-Defensin 2. J Burns Wounds
    37. (2008). Netea MG: Drosomycin-like defensin, a human homologue of Drosophila melanogaster drosomycin with antifungal activity. Antimicrob Agents Chemother
    38. (2001). PB: Discovery of new human beta-defensins using a genomics-based approach. Gene
    39. (2003). R: ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes.
    40. (2000). Rashkovsky L: Generation of complement C3 and expression of cell membrane complement inhibitory proteins by human bronchial epithelium cell line. Thorax
    41. (1986). RD: In vitro killing of spores and hyphae of Aspergillus fumigatus and Rhizopus oryzae by rabbit neutrophil cationic peptides and bronchoalveolar macrophages.
    42. (2004). Regulation of Fungal Infection by a Combination of Amphotericin B and Peptide 2, a Lactoferrin Peptide That Activates Neutrophils. Clin Diagn Lab Immunol
    43. (1999). Remizzi A: Xenogeneic Serum Promotes Leukocyte-Endothelium Interaction under Flow through Two Temporally Distinct Pathways: role of complement and nuclear factorkappaB.
    44. (2008). Reutrakul V: Involvement of phospholipase D in regulating expression of anti-microbial peptide human beta-defensin-2. Int Immunol
    45. (2007). S: Verruculogen associated with Aspergillus fumigatus hyphae and conidia modifies the electrophysiological properties of human nasal epithelial cells.
    46. (1997). Schröder JM: A peptide antibiotic from human skin.
    47. (1999). Selsted M: A cyclic antimicrobial peptide produced in primateleukocytes by the ligation of two truncated a-defensins. Science
    48. Sieg SF: Human -defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2.
    49. (2002). SM: Toll-like receptor (TLR) signaling in response to Aspergillus fumigatus.
    50. (1998). Smaller sized particles are preferentially taken up by alveolar type II pneumocytes.
    51. (2006). Takada H: Toll-like Receptors, NOD1, and NOD2 in Oral Epithelial Cells. J Dent Res
    52. (1999). TJ: Role of TNF-alpha in pulmonary host defense in murine invasive aspergillosis.
    53. (1976). Todaro S: A continuous tumor-cell line from a human lung carcinoma with properties of type II alveolar epithelial cells.
    54. (2007). Triptolide suppresses interleukin-1beta-induced human beta-defensin-2 mRNA expression through inhibition of transcriptional activation of NF-kappaB in A549 cells.
    55. (2002). Uptake of Aspergillus fumigatus Conidia by Phagocytic and Nonphagocytic Cells In Vitro: Quantitation Using Strains Expressing Green Fluorescent Protein. Infect Immun
    56. (1997). Weiss T: Antimicrobial peptides of phagocytes and epithelia. Semin Hematol
    57. (2008). Zipfel PF: The opportunistic human pathogenic fungus Aspergillus fumigatus evades the host complement system. Infect Immun

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.