journal articlereview
oaidoi:10.1016/j.cell.2004.08.023

The Lingering Enigma of the Allelic Exclusion Mechanism

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Publication date
3 September 2004
Publisher
Cell Press.
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    Abstract

    AbstractB lymphocytes produce diverse antibody specificities by “randomly” assembling antibody genes from germline segments. Yet, though each B lymphocyte has multiple allelic loci for the different antibody chains, each clonally derived mature B lymphocyte expresses a single species of antibody with a unique specificity via a process termed allelic exclusion. Despite some progress, the precise mechanism of allelic exclusion remains an enigma

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