journal article
oaidoi:10.1016/0014-5793(88)80935-9

Cleavage of specific sites of RNA by designed ribozymes

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Publication date
7 November 1988
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Published by Elsevier B.V.
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    Abstract

    AbstractTwo ribozymes were designed for site-specific cleavage of RNA. A UA site in an undecaribonucleotide was cleaved by a ribozyme consisting of two partially paired oligoribonucleotides with chain lengths of 19 and 15. The other ribozyme, which consists of a 19-mer and a 13-mer, recognized a UC sequence at positions 42 and 43 of 5 S rRNA

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