journal article
oaidoi:10.1016/0014-5793(85)80977-7

Influence of cyclosporin A on the respiration of isolated rat kidney mitochondria

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Publication date
8 April 1985
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Published by Elsevier B.V.
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    Abstract

    AbstractIn vitro exposure of isolated rat kidney mitochondria to cyclosporin A, a new immunosuppressive agent with serious nephrotoxic side-effects, leads to alterations of both succinate- and glutamate plus malate-supported respiration in a dose-related manner. ADP- and 2,4-dinitrophenol-stimulated respiration, respiratory control indices, and ADP/0 ratios are decreased. The mitochondrial alterations are discussed as possible pathogenetic reasons of cyclosporin A nephrotoxicity.Cyclosporin A toxicityRat kidneyMitochondrion respiratio

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