journal articlereview
oaidoi:10.1016/j.stem.2013.03.008

To Be Immunogenic, or Not to Be: That’s the iPSC Question

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Publication date
4 April 2013
Publisher
Elsevier Inc.
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    Abstract

    The unexpected finding that autologous induced pluripotent stem cell (iPSC)-derived teratomas are immunogenic in syngeneic hosts sparked pessimism over their therapeutic potential; however, two recent reports (Guha et al., 2013 and Araki et al., 2013; the latter in this issue of Cell Stem Cell) contradict previous findings, showing no immunogenicity of in vitro differentiated syngeneic iPS-derived cells and supporting their safety

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