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Interleukin 2 mediates p72syk activation in peripheral blood lymphocytes

By Suofu Qin, Tetsuya Inazu, Cheng Yang, Kiyonao Sada, Takanobu Taniguchi and Hirohei Yamamura


AbstractThe ability of interleukin 2 (IL-2) to stimulate p72syk activity in intact porcine peripheral blood lymphocytes was examined. We demonstrated that IL-2 activated p72syk in a time- and dose-dependent number, for which its peak time and maximum responsive dose were 5 min and 100 U/ml, respectively. This activation was observed only in cytosolic fractions and not in membrane ones. However, IL-2 failed to induced calcium mobilization. Moreover, IL-2-inducible p72syk activation was not affected when extra and intracellular calcium was depleted. These data suggest that the IL-2 signaling pathways through p72syk in peripheral blood lymphocytes is different, at least in part, from other agonist, such as concanavalin A in polymorphonuclear neutrophils which can trigger both the activation of p72syk and intracellular calcium mobilization

Publisher: Published by Elsevier B.V.
Year: 1994
DOI identifier: 10.1016/0014-5793(94)00450-1
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