Binding of gastrin to gastric transferrin

Abstract

AbstractBinding of 125I-gastrin2,17 to porcine gastric transferrin has been demonstrated by covalent cross-linking with disuccinimidyl suberate. The concentration of gastrin17 required to reduce cross-linking by 50% was approx. 100 μM. The occurrence of both gastrin and gastric transferrin in porcine gastric mucosa and lumen suggests a novel synergistic role for the observed interaction in the uptake of dietary iron