journal articlereview
oaidoi:10.1016/j.cell.2011.08.019

A New FOXO Pathway Required for Leukemogenesis

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Publication date
2 September 2011
Publisher
Elsevier Inc.
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    Abstract

    In cancer, the FOXO family of transcription factors functions as tumor suppressors and is directly inactivated by oncogenic signaling through the PI3K/AKT pathway. Now, Skykes et al. (2011) identify a paradoxical requirement for FOXOs in the maintenance of leukemia-initiating cells

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