journal articlereview
oaidoi:10.1016/j.cmet.2008.06.010

The Double Life of Irs

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Publication date
2 July 2008
Publisher
Elsevier Inc.
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    Abstract

    The liver plays a central role in lipid and glucose metabolism. Two studies in this issue (Kubota et al., 2008; Dong et al., 2008) on the insulin-signaling adaptors Irs1 and Irs2 prompt a critical reappraisal of the physiology of fasting and of the integrated control of hepatic insulin action

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