Recurrent Carotid Artery Stenosis Following Endarterectomy: Natural History and Risk Factors

Abstract

AbstractObjectivesTo establish the incidence of restenosis (RES) following carotid endarterectomy (CEA) and evaluate clinical and technical factors related to its development.DesignProspective non-randomised cohort study.Patients and methodsTwo hundred and twenty-four patients with 243 CEA between May 1998 and December 2002, were subjected to clinical and haemodynamic follow-up, median follow-up 23 months (1–56). There was selective use of a shunt (17.3%) and patch (61.7%). RES (≥50%) and severe restenosis, ≥70%, (sRES) were defined as peak systolic velocities of ≥150 and ≥300cm/s (or ≥250cm/s with diastolic velocity >100cm/s), respectively. Rates of RES, symptom development and mortality were analysed using Kaplan–Meier curves. Cox's regression model (hazards ratio/95% CI) was used to evaluate prognostic factors.ResultsWe detected 13 sRES (5.3%) (median time 6.1 months) and 30 (12.3%) moderate stenosis (mRES) (median time 3.7 months). Cumulative freedom from sRES at 23 months was 94.2%. Five sRES detected in the first 45 days after the procedure were deemed to be residual restenosis (rRES). Five (38.4%) sRES were symptomatic, 15.3% progressed to occlusion. Patient survival was 98.0 and 96.4% at 12 and 24 months, respectively. Independent risk factors for sRES: female sex (HR: 3.3, 95% CI 1.1–10 p=0.04) and diabetes (HR: 4.5, 95% CI 1.4–13.9 p=0.008).ConclusionsCarotid restenosis appears early, is usually low-grade and mostly asymptomatic. Although few stenoses progress to occlusion, women and diabetic patients were at highest risk