journal article
oaidoi:10.1016/1044-0305(94)85003-8

Gas-phase hydrogen/deuterium exchange as a molecular probe for the interaction of methanol and protonated peptides

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Publication date
31 July 1994
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Published by Elsevier B.V.
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    Abstract

    AbstractThe gas-phase hydrogen/deuterium (H/D) exchange kinetics of several protonated amino acids and dipeptides under a background pressure of CH3OD were determined in an external source Fourier transform mass spectrometer. H/D exchange reactions occur even when the gas-phase basicity of the compound is significantly larger (> 20 kcal/mol) than methanol. In addition, greater deuterium incorporation is observed for compounds that have multiple sites of similar basicities. A mechanism is proposed that involves a structurally specific intermediate with extensive interaction between the protonated compound and methanol

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