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Plasmid-Mediated qnrB2 and Carbapenemase Gene blaKPC-2 Carried on the Same Plasmid in Carbapenem-Resistant Ciprofloxacin-Susceptible Enterobacter cloacae Isolates▿

By Inna Chmelnitsky, Shiri Navon-Venezia, Jacob Strahilevitz and Yehuda Carmeli


Fourteen out of 16 carbapenem-resistant quinolone-susceptible Enterobacter cloacae isolates were found to carry qnrB2 and blaKPC-2 genes encoded on the same plasmid. One isolate also carried the aac(6′)-Ib-cr gene. Coexistence of quinolone resistance determinants and blaKPC-2 on the same plasmid in quinolone-susceptible E. cloacae isolates may have important clinical implications

Topics: Mechanisms of Resistance
Publisher: American Society for Microbiology (ASM)
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Provided by: PubMed Central
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