Location of Repository

Transmembrane and Ubiquitin-Like Domain-Containing Protein 1 (Tmub1/HOPS) Facilitates Surface Expression of GluR2-Containing AMPA Receptors

By Hyunjeong Yang, Hiroshi Takagi, Yoshiyuki Konishi, Hiroshi Ageta, Koji Ikegami, Ikuko Yao, Showbu Sato, Ken Hatanaka, Kaoru Inokuchi, Dae-Hyun Seog and Mitsutoshi Setou


Some ubiquitin-like (UBL) domain-containing proteins are known to play roles in receptor trafficking. Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) undergo constitutive cycling between the intracellular compartment and the cell surface in the central nervous system. However, the function of UBL domain-containing proteins in the recycling of the AMPARs to the synaptic surface has not yet been reported

Topics: Research Article
Publisher: Public Library of Science
OAI identifier: oai:pubmedcentral.nih.gov:2474703
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles



    1. (1991). A voltage-clamp study of the effects of Joro spider toxin and zinc on excitatory synaptic transmission in CA1 pyramidal cells of the guinea pig hippocampal slice.
    2. (2003). Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system.
    3. (2007). Alternative poly(A) site-selection regulates the production of alternatively spliced vesl-1/homer1 isoforms that encode postsynaptic scaffolding proteins.
    4. (2006). Amino acid transporter ATA2 is stored at the trans-Golgi network and released by insulin stimulus in adipocytes.
    5. (2003). AMPA receptor trafficking at excitatory synapses.
    6. (2008). An excellent monitoring system for surface ubiquitination-induced internalization in mammals.
    7. (2004). Axonal transport versus dendritic transport.
    8. (1991). Ca2+ permeability of KAAMPA–gated glutamate receptor channels depends on subunit composition.
    9. (2002). Clathrin adaptor AP2 and NSF interact with overlapping sites of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTD.
    10. (1994). Cloned glutamate receptors.
    11. (2006). Complex Loci in human and mouse genomes.
    12. (1999). Dynamindependent endocytosis of ionotropic glutamate receptors.
    13. (1996). Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons.
    14. (2001). GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitinlike protein Plic-1.
    15. (2004). GABAA receptor-associated protein traffics GABAA receptors to the plasma membrane in neurons.
    16. (2002). Glutamatereceptor-interacting protein GRIP1 directly steers kinesin to dendrites.
    17. (1997). GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors.
    18. (2000). Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains.
    19. (2008). HOPS is an essential constituent of centrosome assembly.
    20. (2006). Hypo-osmotic shock induces nuclear export and proteasome-dependent decrease of UBL5.
    21. (2000). Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport.
    22. (2007). Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function.
    23. (2000). Mutagenesis reveals a role for ABP/GRIP binding to GluR2 in synaptic surface accumulation of the AMPA receptor.
    24. (2007). Phosphorylation of glutamate receptor interacting protein 1 regulates surface expression of glutamate receptors.
    25. (2005). PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking.
    26. (2006). Regulation of amino acid transporter ATA2 by ubiquitin ligase Nedd4-2.
    27. (2003). Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins.
    28. (2000). Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting.
    29. (2005). Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle.
    30. (2006). SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release.
    31. (2005). sorting and recycling of the glutamate receptor subunit GluR2.
    32. (2002). Structure of GABARAP in two conformations: implications for GABA(A) receptor localization and tubulin binding.
    33. (2004). Subunit rules governing the sorting of internalized AMPA receptors in hippocampal neurons.
    34. (2001). Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons.
    35. (2001). Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons.
    36. (2007). SUMOylation regulates kainate-receptor-mediated synaptic transmission.
    37. (1999). Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSFdependent mechanism.
    38. (2005). Synapse-specific regulation of AMPA receptor subunit composition by activity.
    39. (1997). Synaptically coupled central nervous system neurons lack centrosomal gamma-tubulin.
    40. (1998). Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes.
    41. (2007). The cell biology of synaptic plasticity: AMPA receptor trafficking.
    42. (1998). The ligation systems for ubiquitin and ubiquitin-like proteins.
    43. (2001). The sequence of the human genome. Science 291: 1304–1351. A Factor for
    44. (2007). Transcriptome analysis reveals the population of dendritic RNAs and their redistribution by neural activity.
    45. (2008). TTLL10 is a protein polyglycylase that can modify nucleosome assembly protein
    46. (2006). TTLL7 is a mammalian beta-tubulin polyglutamylase required for growth of MAP2-positive neurites.
    47. (2004). Ubiquitin-dependent regulation of the synapse.
    48. (2003). Ubiquitin-mediated proteasome activity is required for agonist-induced endocytosis of GluRs.
    49. (2003). Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.