Skip to main content
Article thumbnail
Location of Repository

Region-Specific Growth Effects in the Developing Rat Prostate Following Fetal Exposure to Estrogenic Ultraviolet Filters

By Luke Hofkamp, Sarahann Bradley, Jesus Tresguerres, Walter Lichtensteiger, Margret Schlumpf and Barry Timms
Topics: Research
Publisher: National Institute of Environmental Health Sciences
OAI identifier:
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles


    1. (2003). Activation of estrogen receptor α and ERβ by 4-methylbenzylidene-camphor in human and rat cells: comparison with phyto- and xenoestrogens. Toxicol Lett 142:89–101.
    2. (2007). Atrazine-induced aromatase expression is SF-1 dependent: implications for endocrine disruption in wildlife and reproductive cancers in humans. Environ Health Perspect 115:720–727.
    3. (2006). Comparison of effects of estradiol (E2) with those of octylmethoxycinnamate (OMC) and 4-methylbenzylidene camphor (4MBC)—2 filters of UV light—on several uterine, vaginal and bone parameters.
    4. (2006). Comparison of effects of estradiol with those of octylmethoxycinnamate and 4-methylbenzylidene camphor on fat tissue, lipids and pituitary hormones.
    5. (2006). Concentrations and specific loads of UV filters in sewage sludge originating from a monitoring network in Switzerland.
    6. (2002). Confirmation of uterotrophic activity of 3-(4-methylbenzylidene) camphor in the immature rat. Environ Health Perspect 110:533–536.
    7. (1986). Council Directive 86/609/EEC of 24
    8. (2008). Developmental toxicity of UV filters and environmental exposure: a review.
    9. (1994). Ductal budding and branching patterns in the developing prostate.
    10. (2005). Early prostate development and its association with late-life prostate disease. Cell Tissue Res 322:173–181.
    11. (2004). Endocrine activity and developmental toxicity of cosmetic UV filters—an update.
    12. (2007). Estradiol and bisphenol a stimulate androgen receptor and estrogen receptor gene expression in fetal mouse prostate mesenchyme cells. Environ Health Perspect 115:902–908.
    13. (2007). Estrogen sensitivity of target genes and expression of nuclear receptor coregulators in rat prostate after pre- and postnatal exposure to the ultraviolet filter 4-methylbenzylidene camphor. Environ Health Perspect 115(suppl 1):42–50.
    14. (2005). Estrogen target gene regulation and coactivator expression in rat uterus after developmental exposure to the ultraviolet filter 4-methylbenzylidene camphor. Endocrinology 146:2130–2139.
    15. (2004). Estrogenic activity and estrogen receptor beta binding of the UV filter 3-benzylidene camphor. Comparison with 4-methylbenzylidene camphor.
    16. (2004). Estrogenic regulation of signaling pathways and homeobox genes during rat prostate development.
    17. (2006). Fate and removal of polycyclic musks, UV filters and biocides during wastewater treatment.
    18. (2001). In vitro and in vivo estrogenicity of UV screens. Environ Health Perspect 109:239–244.
    19. (2007). Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor.
    20. (1995). Instructive induction of prostate growth and differentiation by a defined urogenital sinus mesenchyme.
    21. (2005). Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays. Toxicol Sci 83:264–272.
    22. (2008). Mandate to the SCCP–Evaluation of Additional Studies Concerning the Safety of 4-Methylbenzylidene Camphor. Available: 04_sccp/docs/sccp_q_171.pdf [accessed 15
    23. (1991). Morphological and functional heterogeneity in the rat prostatic gland. Biol Reprod 45:308–321.
    24. (1992). Neonatal estrogen exposure induces lobespecific alterations in adult rat prostate androgen receptor expression.
    25. (2005). Occurrence of some organic UV filters in wastewater, in surface waters, and in fish from Swiss Lakes. Environ Sci Technol 39:953–962.
    26. (2006). Occurrence of UV filters 4-methylbenzylidene camphor and octocrylene in fish from various Swiss rivers with inputs from wastewater treatment plants. Environ Sci Technol 40:1427–1431.
    27. (2003). Over-the-counter drug products; safety and efficacy revew; additional sunscreen ingredients. Fed Reg 68:41386.
    28. (1997). Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses. Proc Natl Acad Sci USA 94:2056–2061.
    29. (1999). Prostate gland growth during development is stimulated in both male and female rat fetuses by intrauterine proximity to female fetuses.
    30. (2007). Regulation of Wolffian duct development. Horm Res 67:142–151.
    31. (2007). Risk assessment of topically applied products.
    32. (2004). Role of stromal-epithelial interactions in hormonal responses.
    33. (2007). Sexually dimorphic gene regulation in brain as a target for endocrine disrupters: developmental exposure of rats to 4-methylbenzylidene camphor.
    34. (2005). Stereoisomer composition of the chiral UV filter 4-methylbenzylidene camphor in environmental samples. Environ Sci Technol 39:3013–3019.
    35. (1974). Testosterone formation and metabolism during male sexual differentiation in the human embryo.
    36. (2007). The role of estrogens and estrogen receptors in normal prostate growth and disease.
    37. (2006). The role of estrogens in normal and abnormal development of the prostate gland.
    38. (2005). The role of Fgf10 signaling in branching morphogenesis and gene expression of the rat prostate gland: lobe-specific suppression by neonatal estrogens.
    39. (2002). The role of smooth muscle in regulating prostatic induction. Development 129:1905–1912. UV filters and fetal prostate development Environmental Health Perspectives •
    40. (2006). Toxicokinetics and biotransformation of 3-(4-methylbenzylidene)camphor in rats after oral administration.
    41. (2003). UV filters with antagonistic action at androgen receptors in the MDA-kb2 cell transcriptional-activation assay. Toxicol Sci 74:43–50.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.