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Piperazine catalyzed convenient synthesis of 4H-pyran derivatives from α,α′-bis(substituted-benzylidene) cycloalkanones and malononitrile under reflux conditions

By Akbar Mobinikhaledi, Naser Foroughifar, Hassan Moghanian and Nahid Keshavarzi


AbstractA facile, simple and convenient method for the synthesis of 4H-pyran derivatives has been achieved through the condensation reactions of α,α′-bis(substituted-benzylidene) cycloalkanones and malononitrile in the presence of piperazine as an odorless and easy to work catalyst under reflux conditions. With the optimized reaction conditions, the desired products were obtained with 62–82% yields

Publisher: Production and hosting by Elsevier B.V.
Year: 2015
DOI identifier: 10.1016/j.jscs.2012.05.001
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