Location of Repository

Dynamic instability of the major urinary protein gene family revealed by genomic and phenotypic comparisons between C57 and 129 strain mice

By Jonathan M Mudge, Stuart D Armstrong, Karen McLaren, Robert J Beynon, Jane L Hurst, Christine Nicholson, Duncan H Robertson, Laurens G Wilming and Jennifer L Harrow


Targeted sequencing, manual genome annotation, phylogenetic analysis and mass spectrometry were used to characterise major urinary proteins (MUPs) and the Mup clusters of two strains of inbred mice

Topics: Research
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:2441477
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles



    1. (2006). Kendrick KM: Mammalian social odours: attraction and individual recognition.
    2. (2000). Mucignat-Caretta C: Major urinary proteins, alpha(2U)-globulins and aphrodisin. Biochim Biophys Acta
    3. (2004). Urinary proteins and the modulation of chemical scents in mice and rats. Peptides
    4. (2007). Identification of protein pheromones that promote aggressive behaviour. Nature
    5. (2003). Towards an understanding of the pregnancy-blocking urinary chemosignals of mice. Biochem Soc Trans
    6. (2007). JL: The genetic basis of individual-recognition signals in the mouse. Curr Biol
    7. (2007). Individual recognition: mice, MUPs and the MHC. Curr Biol
    8. (1992). Estrus female house mice discriminate dominant from subdominant males and sons of subordinate males by odor cues. Anim Behav
    9. (2001). RJ: Individual recognition in mice mediated by major urinary proteins. Nature
    10. (1999). TJ: Scent marks as competitive signals of mate quality. Anim Behav
    11. (1999). ZĂ­dek L: Positive identification of the puberty-accelerating pheromone of the house mouse: the volatile ligands associating with the major urinary protein. Proc Biol Sci
    12. (2007). JL: The genetic basis of inbreeding avoidance in house mice. Curr Biol
    13. (2008). JL: The direct assessment of genetic heterozygosity through scent in the mouse. Curr Biol
    14. (1992). Cavaggioni A: Pheromone binding proteins of the mouse, Mus musculus. Experientia
    15. (1991). Cavaggioni A: Crystallization of and preliminary X-ray data for the mouse major urinary protein and rat alpha-2u globulin.
    16. (1996). RJ: Molecular heterogeneity in the major urinary proteins of the house mouse Mus musculus.
    17. (1998). RJ: Proteins in urine scent marks of male house mice extend the longevity of olfactory signals. Anim Behav
    18. (2003). JL: Multiple roles of major urinary proteins in the house mouse, Mus domesticus. Biochem Soc Trans
    19. (2005). RJ: MHC odours are not required or sufficient for recognition of individual scent owners. Proc Biol Sci
    20. (1963). CR: Electrophoretic variation and sex dimorphism of the major urinary protein complex in inbred mice: a new genetic marker.
    21. (2005). RJ: Structural and functional differences in isoforms of mouse major urinary proteins: a male-specific protein that preferentially binds a male pheromone.
    22. (2002). MJ: Pheromone binding by polymorphic mouse major urinary proteins. Protein Sci
    23. (1987). Derman E: Expression of six mouse major urinary protein genes in the mammary, parotid, sublingual, submaxillary, and lachrymal glands and in the liver. Mol Cell Biol
    24. (1987). E: Nucleotide sequences of liver, lachrymal, and submaxillary gland mouse major urinary protein mRNAs: mosaic structure and construction of panels of gene-specific synthetic oligonucleotide probes. Mol Cell Biol
    25. (2000). Genealogies of mouse inbred strains. Nat Genet
    26. (1985). AJ: The 45-kb unit of major urinary protein gene organization is a gigantic imperfect palindrome. Mol Cell Biol
    27. (1984). A 45-kb DNA domain with two divergently orientated genes is the unit of organisation of the murine major urinary protein genes.
    28. (1989). Derman E: Silent genes in the mouse major urinary protein gene family.
    29. (2000). L: Contigs built with fingerprints, markers, and FPC V4.7. Genome Res
    30. (2004). Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence.
    31. (2007). DC: Validation of rice genome sequence by optical mapping.
    32. The Ensembl Genome Browser [http://www.ensembl.org]
    33. T: The Vertebrate Genome Annotation (Vega) database. Nucleic Acids Res 2005, 33(Database issue):D459-D465.
    34. (2006). HD: The surprising complexity of signal sequences. Trends Biochem Sci
    35. (2004). Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature
    36. (2000). DC: Deletion of azoospermia factor a (AZFa) region of human Y chromosome caused by recombination between HERV15 proviruses. Hum Mol Genet
    37. (2005). A: A genome-wide, end-sequenced 129Sv BAC library resource for targeting vector construction. Genomics
    38. (2005). Daly MJ: Genetic variation in laboratory mice.
    39. (2002). MJ: The mosaic structure of variation in the laboratory mouse genome. Nature
    40. (2007). Recurrent DNA copy number variation in the laboratory mouse. Nat Genet
    41. (2006). MV: Know thy mouse. Trends Genet
    42. (2002). Initial sequencing and comparative analysis of the mouse genome. Nature
    43. (1993). Multiple binding sites for nuclear factors in the 5'-upstream region of two alpha 2u-globulin genes: implications for hormone-regulated and tissue-specific control.
    44. (1987). Comparison of the 5' upstream putative regulatory sequences of three members of the alpha 2uglobulin gene family.
    45. (2007). RJ: Characterization and comparison of major urinary proteins from the house mouse, Mus musculus domesticus, and the aboriginal mouse, Mus macedonicus.
    46. (2004). Evolution and comparative genomics of odorant- and pheromone-associated genes in rodents. Genome Res
    47. (1972). E: A comparison of the ribosomal DNA's of Xenopus laevis and Xenopus mulleri: the evolution of tandem genes.
    48. (2004). SS: Origins of chromosomal rearrangement hotspots in the human genome: evidence from the AZFa deletion hotspots. Genome Biol
    49. (1997). Momigliano Richiardi P: Evidence for gene conversion in the generation of extensive polymorphism in the promoter of the growth hormone gene. Hum Genet
    50. (2002). Are 100,000 "SNPs" useless? Science
    51. (2007). TJ: A high-resolution map of segmental DNA copy number variation in the mouse genome. PLoS Genet
    52. (2005). AP: Concerted and birth-and-death evolution of multigene families. Annu Rev Genet
    53. (1993). F: The evolution of house mice. Ann Rev Ecol System
    54. (2004). spatial, and ecological modes of evolution of Eurasian Mus based on mitochondrial and nuclear gene sequences. Mol Phylogenet Evol
    55. (1943). Auffray J-C: First occurrence of the house mouse (Mus musculus domesticus Schwarz & Schwarz,
    56. Humphries RE: Urinary lipocalins in Rodenta. Is there a generic model?
    57. Balanced Polymorphism and Evolution by the
    58. (1994). Odorant-binding proteins. Crit Rev Biochem Mol Biol
    59. (1992). Sexual dimorphism and growth hormone regulation of a hybrid gene in transgenic mice. Mol Endocrinol
    60. (1976). Feigelson P: Effect of thyroid hormones on the level of the hepatic mRNA for alpha2u globulin. Biochemistry
    61. (1987). Glucocorticoid receptor binding to defined regions of alpha 2u-globulin genes. Biochem Biophys Res Commun
    62. (1978). Paigen K: Regulation of mouse major urinary protein production by the Mup-A gene. Genetics
    63. (1993). Adult phenotype in the mouse can be affected by epigenetic events in the early embryo. Development
    64. (1997). Epigenetic inheritance in the mouse. Curr Biol
    65. (1987). Differences in DNA methylation during oogenesis and spermatogenesis and their persistence during early embryogenesis in the mouse. Genes Dev
    66. The ExPASy Proteomics Server [http://www.expasy.org]
    67. (1980). Held WA: In vitro synthesis and characterisation of precursors to the mouse major urinary proteins.
    68. (2000). Repbase update: a database and an electronic journal of repetitive elements. Trends Genet
    69. (1994). CLUSTAL V: multiple alignment of DNA and protein sequences. Methods Mol Biol
    70. PHYLIP - Phylogeny Inference Package (Version
    71. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature
    72. (1999). Probability-based protein identification by searching sequence databases using mass spectrometry data. Electrophoresis

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.