Location of Repository

The SsgA-like proteins in actinomycetes: small proteins up to a big task

By Bjørn A. Traag and Gilles P. van Wezel

Abstract

Several unique protein families have been identified that play a role in the control of developmental cell division in streptomycetes. The SsgA-like proteins or SALPs, of which streptomycetes typically have at least five paralogues, control specific steps of sporulation-specific cell division in streptomycetes, affecting cell wall-related events such as septum localization and synthesis, thickening of the spore wall and autolytic spore separation. The expression level of SsgA, the best studied SALP, has a rather dramatic effect on septation and on hyphal morphology, which is not only of relevance for our understanding of (developmental) cell division but has also been succesfully applied in industrial fermentation, to improve growth and production of filamentous actinomycetes. Recent observations suggest that SsgB most likely is the archetypal SALP, with only SsgB orthologues occurring in all morphologically complex actinomycetes. Here we review 10 years of research on the SsgA-like proteins in actinomycetes and discuss the most interesting regulatory, functional, phylogenetic and applied aspects of this relatively unknown protein family

Topics: Original Paper
Publisher: Springer Netherlands
OAI identifier: oai:pubmedcentral.nih.gov:2440963
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Preview

    Citations

    1. (2003). (2000b) Effects of increased and deregulated expression of cell division genes on the morphology and on antibiotic production of streptomycetes. Antonie Van Leeuwenhoek 78:269–276 van Wezel GP, Vijgenboom E
    2. (2001). Dynamic proteins in bacteria.
    3. (2002). Effects of multiple deletions of murein hydrolases on Antonie van Leeuwenhoek (2008) 94:85–97 95 123viability, septum cleavage, and sensitivity to large toxic molecules in Escherichia coli. J Bacteriol 184:6093–6099 Holtje JV
    4. (2004). Identification of sigmaB-dependent promoters using consensus-directed search of Streptomyces coelicolor genome.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.