Microenvironmental stresses induce HLA-E/Qa-1 surface expressionand thereby reduce CD8(+) T-cell recognition of stressed cells.
Abstract
腫瘍微小環境ストレスがCD8+T細胞応答を介した免疫応答に与える影響に関しては知られていない. 我々は微小環境ストレス（低酸素, グルコース飢餓）により腫瘍細胞表面の非古典的MHC class Ib (Qa-1b, HLA-E)発現が上昇し, 特異的CD8+T細胞応答を低下させることを明らかにしたSimilar works
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Last time updated on 14/04/2017
This paper was published in sapporo medical university Information and KnOwledge Repository).
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