Article thumbnail

CD47 associates with alpha 5 integrin and regulates responses of human articular chondrocytes to mechanical stimulation in an in vitro model

By Mahmoud Orazizadeh, Herng Sheng Lee, Bianca Groenendijk, S Jane Millward Sadler, Malcolm O Wright, Frederik P Lindberg and Donald M Salter
Topics: Research Article
Publisher: BioMed Central
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (1993). A 50-kDa integrin-associated protein is required for integrin-regulated calcium entry in endothelial cells.
  2. (1997). A: Integrin-associated protein (CD47) is a comitogenic molecule on CD3-activated human T cells.
  3. (2000). B: Expression of thrombospondin-1 and its receptor CD36 in human osteoarthritic cartilage. Ann Rheum Dis
  4. (1994). Cartilage oligomeric matrix protein and thrombospondin 1. Purification from articular cartilage, electron microscopic structure, and chondrocyte binding.
  5. (1997). DL: Compressive strains at physiological frequencies influence the metabolism of chondrocytes seeded in agarose.
  6. (2000). DM: Altered electrophysiological responses to mechanical stimulation and abnormal signalling through alpha5beta1 integrin in chondrocytes from osteoarthritic cartilage. Osteoarthritis Cartilage
  7. (2004). DM: ATP in the mechanotransduction pathway of normal human chondrocytes. Biorheology
  8. (2000). DM: Integrin and mechanosensitive ion channel-dependent tyrosine phosphorylation of focal adhesion proteins and beta-catenin in human articular chondrocytes after mechanical stimulation. J Bone Miner Res
  9. (2000). DM: Mechanotransduction via integrins and interleukin-4 results in altered aggrecan and matrix metalloproteinase 3 gene expression in normal, but not osteoarthritic, human articular chondrocytes. Arthritis Rheum
  10. (1997). EJ: Costimulation of T cell activation by integrin-associated protein (CD47) is an adhesion-dependent, CD28-independent signaling pathway. J Exp Med
  11. (1996). EJ: Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice. Science
  12. (1995). EJ: Integrin beta 3 cytoplasmic tail is necessary and sufficient for regulation of alpha 5 beta 1 phagocytosis by alpha v beta 3 and integrinassociated protein.
  13. (1996). EJ: Integrin-associated protein immunoglobulin domain is necessary for efficient vitronectin bead binding.
  14. (1993). EJ: Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding.
  15. (1999). EJ: Role of cholesterol in formation and function of a signaling complex involving alphavbeta3, integrin-associated protein (CD47), and heterotrimeric G proteins.
  16. (2003). EJ: The ubiquitin-related protein PLIC-1 regulates heterotrimeric G protein function through association with G betagamma.
  17. (1999). EJ: Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane. Mol Cell
  18. (1997). Electrophysiological responses of human bone cells to mechanical stimulation: evidence for specific integrin function in mechanotransduction. J Bone Miner Res
  19. (2004). Frazier WA: CD47 mediates killing of breast tumor cells via Gi-dependent inhibition of protein kinase A. Cancer Res
  20. (1994). Frazier WA: Identification of a receptor candidate for the carboxyl-terminal cell binding domain of thrombospondins.
  21. (2001). Frazier WA: Integrin-associated protein (CD47) and its ligands. Trends Cell Biol
  22. (2001). GA: An RGD sequence in the P2Y(2) receptor interacts with alpha(V)beta(3) integrins and is required for G(o)-mediated signal transduction.
  23. (2004). Grodzinsky AJ: Mechanical compression of cartilage explants induces multiple time-dependent gene expression patterns and involves intracellular calcium and cyclic AMP.
  24. (1992). Heinegard D: Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage.
  25. (1993). Helminen H: Proteoglycan alterations in rabbit knee articular cartilage following physical exercise and immobilization. Connect Tiss Res
  26. (1993). Helminen HJ: Effects of cyclic hydrostatic pressure on proteoglycan synthesis in cultured chondrocytes and articular cartilage explants. Arch Biochem Biophys
  27. (2000). Immunol
  28. (1989). JD: Biosynthetic response of cartilage explants to dynamic compression.
  29. (2001). MD: Cartilage oligomeric matrix protein interacts with type IX collagen, and disruptions to these interactions identify a pathogenetic mechanism in a bone dysplasia family.
  30. MH: CD47 is a ligand for rat macrophage membrane signal regulatory protein SIRP (OX41) and human SIRPalpha
  31. (2005). RL: Fluid shear-induced ATP secretion mediates prostaglandin release in MC3T3-E1 osteoblasts.
  32. (2002). Roberts DD: Regulation of integrin function by CD47 ligands. Differential effects on alpha vbeta 3 and alpha 4beta1 integrinmediated adhesion.
  33. (2000). S: Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes.
  34. (1997). Salter DM: Hyperpolarisation of cultured human chondrocytes following cyclical pressureinduced strain: evidence of a role for alpha 5 beta 1 integrin as a chondrocyte mechanoreceptor.
  35. (1999). Salter DM: Integrin-regulated secretion of interleukin 4: a novel pathway of mechanotransduction in human articular chondrocytes.
  36. (1999). Sarfati M: CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia. Nat Med
  37. (1980). The Aetiopathogenesis of Osteoarthrosis London,
  38. (1998). The thrombospondin receptor CD47 (IAP) modulates and associates with alpha2 beta1 integrin in vascular smooth muscle cells. Mol Biol Cell
  39. (1999). The thrombospondin receptor integrin-associated protein (CD47) functionally couples to heterotrimeric Gi.
  40. (1996). Thrombospondin modulates alpha v beta 3 function through integrin-associated protein.
  41. (2003). Thrombospondin-bound integrin-associated Protein (CD47) physically and functionally modifies integrin {alpha}IIb{beta}3 by its extracellular domain.
  42. (1997). Thrombspondin acts via integrinassociated protein to activate the platelet integrin alphaIIbbeta3.
  43. (2003). Towle CA: A role for the interleukin-1 receptor in the pathway linking static mechanical compression to decreased proteoglycan synthesis in surface articular cartilage. Arch Biochem Biophys