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Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection course

By Giulia Freer, Donatella Matteucci, Paola Mazzetti, Francesca Tarabella, Enrica Ricci, Leonia Bozzacco, Antonio Merico, Mauro Pistello, Luca Ceccherini-Nelli and Mauro Bendinelli


Immunotherapy of feline immunodeficiency virus (FIV)-infected cats with monocyte-derived dendritic cells (MDCs) loaded with aldrithiol-2 (AT2)-inactivated homologous FIV was performed. Although FIV-specific lymphoproliferative responses were markedly increased, viral loads and CD4+ T cell depletion were unaffected, thus indicating that boosting antiviral cell-mediated immunity may not suffice to modify infection course appreciably

Topics: Short Report
Publisher: BioMed Central
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Provided by: PubMed Central

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