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Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection course

By Giulia Freer, Donatella Matteucci, Paola Mazzetti, Francesca Tarabella, Enrica Ricci, Leonia Bozzacco, Antonio Merico, Mauro Pistello, Luca Ceccherini-Nelli and Mauro Bendinelli

Abstract

Immunotherapy of feline immunodeficiency virus (FIV)-infected cats with monocyte-derived dendritic cells (MDCs) loaded with aldrithiol-2 (AT2)-inactivated homologous FIV was performed. Although FIV-specific lymphoproliferative responses were markedly increased, viral loads and CD4+ T cell depletion were unaffected, thus indicating that boosting antiviral cell-mediated immunity may not suffice to modify infection course appreciably

Topics: Short Report
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:2373306
Provided by: PubMed Central

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Citations

  1. (2004). Andrieu JM: Therapeutic dendritic-cell vaccine for chronic HIV-1 infection. Nat Med
  2. (2003). Andrieu JM: Therapeutic dendriticcell vaccine for simian AIDS. Nat Med
  3. (2000). Antiviral CD4 and CD8 T-cell memory: differences in the size of the response and activation requirements.
  4. (2008). Evaluation of feline monocyte-derived dendritic cells loaded with internally inactivated virus as a vaccine against feline immunodeficiency virus. Clin Vaccine Immunol
  5. FIV as a model for HIV: an overview.
  6. (2005). Generation of feline dendritic cells derived from peripheral blood monocytes for in vivo use. Clin Diagn Lab Immunol
  7. (2003). Gilboa E: Injection of immature dendritic cells into adjuvant-treated skin obviates the need for ex vivo maturation.
  8. (2002). Lanzavecchia A: The instructive role of dendritic cells on T-cell responses. Arthritis Res
  9. (2008). P: The use of dendritic cells in cancer immunotherapy. Crit Rev Oncol Hematol
  10. (2006). SA: Immunological correlates of protection from HIV infection and disease. Nat Immunol
  11. (2007). Taking dendritic cells into medicine. Nature
  12. (1996). Vaccination protects against in vivo-grown feline immunodeficiency virus even in the absence of detectable neutralizing antibodies.

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