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The chemokine RANTES is secreted by human melanoma cells and is associated with enhanced tumour formation in nude mice

By U Mrowietz, U Schwenk, S Maune, J Bartels, M Küpper, I Fichtner, J-M Schröder and D Schadendorf


Modulation of tumour cell growth by tumour-infiltrating leucocytes is of high importance for the biological behaviour of malignant neoplasms. In melanoma, tumour-associated macrophages (TAM) and tumour-infiltrating lymphocytes (TIL) are of particular interest as inhibitors or enhancers of cell growth. Recruitment of leucocytes from the peripheral blood into the tumour site is mediated predominantly by chemotaxins, particularly by the group of chemokines

Topics: Regular Article
Publisher: Nature Publishing Group
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Provided by: PubMed Central
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