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Epigallocatechin-3-gallate (EGCG) inhibits the migratory behavior of tumor bronchial epithelial cells

By Salma Hazgui, Arnaud Bonnomet, Béatrice Nawrocki-Raby, Magali Milliot, Christine Terryn, Jérôme Cutrona, Myriam Polette, Philippe Birembaut and Jean-Marie Zahm
Topics: Research
Publisher: BioMed Central
OAI identifier:
Provided by: PubMed Central

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  1. (2005). A: Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells. Carcinogenesis
  2. (2003). Akizawa T: Inhibitory effect of green tea polyphenols on membrane-type 1 matrix metalloproteinase, MT1-MMP. Biol Pharm Bull
  3. (2001). Albini A: Tumor gelatinases and invasion inhibited by the green tea flavanol epigallocatechin-3-gallate. Cancer
  4. (1998). Birembaut P: Association of fibroblastoid features with the invasive phenotype in human bronchial cancer cell lines. Clin Exp Metastasis
  5. (2003). Birembaut P: E-Cadherin mediates MMP down-regulation in highly invasive bronchial tumor cells.
  6. (1997). Birembaut P: Expression of matrix metalloproteinases and their inhibitors in human bronchopulmonary carcinomas: quantificative and morphological analyses.
  7. (2001). Birembaut P: Quantitative cell dispersion analysis: new test to measure tumor cell aggressiveness.
  8. Birembaut P: Vimentin contributes to human mammary epithelial cell migration.
  9. (2005). Cancer therapy through control of cell migration. Curr Cancer Drug Targets
  10. (2007). CJ: Green tea catechin inhibits ephrinA1-mediated cell migration and angiogenesis of human umbilical vein endothelial cells.
  11. (1998). CY: Induction of apoptosis in prostate cancer cell lines by the green tea component,
  12. (2004). Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor kappa B and induction of apoptosis. Oncogene
  13. (1997). EW: Implication of collagen type I-induced membrane-type 1-matrix metalloproteinase expression and matrix metalloproteinase-2 activation in the metastatic progression of breast carcinoma. Lab Invest
  14. (1994). Foidart JM: Epithelial-tomesenchymal transition in HPV-33-transfected cervical keratinocytes is associated with increased invasiveness and expression of gelatinase A.
  15. (1999). GI: Matrix metalloproteinases in tumour invasion and metastasis.
  16. (2005). GS: Anti-proliferative and proapoptotic effects of (-)-epigallocatechin-3-gallate on human melanoma: possible implications for the chemoprevention of melanoma.
  17. (2007). H: Green tea polyphenol EGCG sensitizes human prostate carcinoma LNCaP cells to TRAIL-mediated apoptosis and synergistically inhibits biomarkers associated with angiogenesis and metastasis. Oncogene
  18. (2003). Iguchi A: Green tea catechins inhibit the cultured smooth muscle cell invasion through the basement barrier. Atherosclerosis
  19. (2005). Iguchi A: Mechanisms of the inhibitory effect of epigallocatechin-3-gallate on cultured human vascular smooth muscle cell invasion. Arterioscler Thromb Vasc Biol
  20. (1998). Impaired mechanical stability, migration and contractile capacity in vimentin-deficient fibroblasts.
  21. (2003). Induction of apoptosis by EGCG in selected tumour cell lines in vitro. Folia Histochem Cytobiol
  22. (1981). Influence of collagen gel on the orientation of epithelial cell polarity: follicle formation from isolated thyroid cells and from preformed monolayers.
  23. (2003). IP: Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions.
  24. (2004). Iwasaka T: The tea polyphenol, (-)-epigallocatechin gallate effects on growth, apoptosis, and telomerase activity in cervical cell lines. Gynecol Oncol
  25. (2005). JM: 3D culture model and computer-assisted videomicroscopy to analyze migratory behavior of noninvasive and invasive bronchial epithelial cells.
  26. (2004). Katiyar SK: EGCG down-regulates telomerase in human breast carcinoma MCF-7 cells, leading to suppression of cell viability and induction of apoptosis.
  27. (1989). KleinSzanto AJ: Expression of type IV collagenase and procollagen genes and its correlation with the tumorigenic, invasive, and metastatic abilities of oncogene-transformed human bronchial epithelial cells. Cancer Res
  28. (1996). Komiya T: Induction of programmed cell death (apoptosis) in human lymphoid leukemia cells by catechin compounds. Anticancer Res
  29. (2001). Liang YC: Inhibition of melanoma growth and metastasis by combination with (-)-epigallocatechin-3-gallate and dacarbazine in mice.
  30. (2003). M: Green tea catechins inhibit VEGF-induced angiogenesis in vitro through suppression of VE-cadherin phosphorylation and inactivation of Akt molecule.
  31. (2003). Matsui-Yuasa I: Green tea extract inhibits angiogenesis of human umbilical vein endothelial cells through reduction of expression of VEGF receptors. Life Sci
  32. (2004). NE: VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia. Blood
  33. (2002). Pezzato E, Garbisa S: (-)Epigallocatechin-3-gallate directly inhibits MT1-MMP activity, leading to accumulation of nonactivated MMP-2 at the cell surface. Lab Invest
  34. (1998). Proteases--invasion and more. Nature
  35. (1997). Puchelle E: Cell migration and proliferation during the in vitro wound repair of the respiratory epithelium. Cell Motil Cytoskeleton
  36. (2002). R: Green tea polyphenol (-)-epigallocatechin 3-gallate inhibits MMP-2 secretion and MT1-MMP-driven migration in glioblastoma cells. Biochim Biophys Acta
  37. (2005). Repressions of MMP-9 expression and NFkappa B localization are involved in inhibition of lung carcinoma 95-D cell invasion by (-)-epigallocatechin-3-gallate. Biomed Pharmacother
  38. (2008). RK: EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer. Front Biosci
  39. (2005). Shimosegawa T: Green tea polyphenol epigallocatechin-3-gallate blocks PDGFinduced proliferation and migration of rat pancreatic stellate cells.
  40. (1997). Skrzypczak-Jankun E: Why drinking green tea could prevent cancer. Nature
  41. (1991). Stetler-Stevenson WG: Tumor invasion and metastasis: an imbalance of positive and negative regulation. Cancer Res
  42. (2002). T: Expression of membrane-type-1-matrix metalloproteinase and metalloproteinase-2 in nonsmall cell lung carcinomas. Lung Cancer
  43. (2005). The intermediate filament protein vimentin is a new target for epigallocatechin gallate.
  44. (2003). Tong WY: Inhibition of liver cancer cell proliferation and migration by a combination of (-)-epigallocatechin-3-gallate and ascorbic acid.
  45. (2005). VB: Catechins prevent vascular smooth muscle cell invasion by inhibiting MT1-MMP activity and MMP-2 expression. Cardiovasc Res
  46. (2002). Werb Z: New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer
  47. (2000). Yang CS: Effect of black and green tea polyphenols on c-jun phosphorylation and H(2)O(2) production in transformed and non-transformed human bronchial cell lines: possible mechanisms of cell growth inhibition and apoptosis induction. Carcinogenesis

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