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The risk of cancer in HIV-infected people in southeast England: a cohort study

By A Newnham, J Harris, H S Evans, B G Evans and H Møller

Abstract

This study used data from the Communicable Disease Surveillance Centre's national HIV database and the Thames Cancer Registry to assess the risk of cancer in HIV-infected people in southeast England. Among 26 080 HIV-infected men with 158 660 person-years follow-up, 1851 cancers, and among 7110 HIV-infected women (31 098 person-years), 171 cancers were identified. The standardised incidence ratio (SIR) for all non-AIDS-defining cancers was significantly increased in HIV-infected men (2.8, 95% confidence interval (CI) 2.6–3.1) but was nonsignificant in HIV-infected women (1.1, 95% CI 0.8–1.6). Most of the cancers observed were in men (n=1559) and women (n=127) with AIDS, and among them, the SIR for all non-AIDS-defining cancers was significantly increased in men (8.2, 95% CI 7.2–9.2) and women (2.8, 95% CI 1.6–4.6). The SIR for all non-AIDS-defining cancers was only just significantly increased in men with HIV-infection but not AIDS (1.2, 95% CI 1.0–1.5) and was nonsignificant in such women (0.8, 95% CI 0.5–1.2)

Topics: Epidemiology
Publisher: Nature Publishing Group
OAI identifier: oai:pubmedcentral.nih.gov:2361741
Provided by: PubMed Central
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    Citations

    1. (2003). Cumulative UK data to end
    2. (2003). Incidence of malignant neoplasms among HIV-infected persons in Scotland.
    3. (2002). Rates of non-AIDS-defining cancers in people with HIV-infection before and after AIDS diagnosis.

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