Effect of increased hydrostatic pressure on lymphatic elimination of hyaluronan from sheep lung

Abstract

pressure on lymphatic elimination of hyaluronan from sheep lung. J. Appl. Physiol. 64(4): 1327-1332, 1988.-The effects of increased hydrostatic pressure on the concentrations of hyalu-ronan (hyaluronic acid) in lung lymph and serum were inves-tigated in awake sheep with a cannula in the efferent vessel from the caudal mediastinal lymph node. Lung lymph was sampled at base line [left atria1 pressure (LAP) 6.5 k 1.7 mmHg] and after two increases of LAP to 25.7 t 2.2 mmHg (be1 1) and 37.0 t 5.1 mmHg (leuel2). The lung lymph flow increased from 1.9 t 0.5 at base line to 9.3 t 2.2 and 15.9 t 0.7 ml/30 min, and the lymph-to-plasma concentration ratio of total protein decreased from 0.63 & 0.02 to 0.32 t 0.04 and 0.32 t 0.05 at the two elevated levels of LAP, respectively. The hyaluronan concentration in lung lymph was unchanged, and there was a flow-dependent elimination of hyaluronan from th