Yellow nail syndrome is a relatively rare disease that is character-ized by yellow nail, lymphedema and pleural effusion. These symp-toms occur to various degrees, but occasionally pleural effusions are interactive and can become life-threatening. We report the case of a 15-year-old girl with yellow nail syndrome with interactive bilateral pleural effusions who was treated with pleuroperitoneal shunting. Drainage from the pleural cavity to the peritoneal cav-ity improved oxygenation and permitted removal of bilateral chest tubes that had been inserted for long term relief. We discuss the benefits and difficulties of this procedure and define the character-istics of patients with yellow nail syndrome who were treated with pleuroperitoneal shunt for pleural effusions, based on a literature review. The procedure may be an alternative rescue strategy for pa-tients with interactive pleural effusions
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