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Affinity of Doripenem and Comparators to Penicillin-Binding Proteins in Escherichia coli and Pseudomonas aeruginosa▿

By Todd A. Davies, Wenchi Shang, Karen Bush and Robert K. Flamm


Doripenem, a parenteral carbapenem, exhibited high affinity for penicillin-binding protein 2 (PBP2) and PBP3 in Pseudomonas aeruginosa and PBP2 in Escherichia coli, the primary PBPs whose inhibition leads to cell death. This PBP affinity profile correlates with the broad-spectrum gram-negative activity observed with doripenem

Topics: Mechanisms of Action: Physiological Effects
Publisher: American Society for Microbiology (ASM)
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Provided by: PubMed Central
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