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P2-M Systematic PTM Analysis of Protein Kinases Using LC-MS/MS Data

By D. C. Chamrad, S. Bailey, A. Wattenberg, C. Beisenherz-Huss, R. Graeser, D. Müller and M. Blueggel


Available peptide fragmentation interpretation software is focused on sequence database–driven protein identification, rather than on primary structure elucidation. Searching for posttranslational modification (PTM) or sequence errors currently needs time-critical manual intervention and evaluation. Here we describe the results and performance of a novel interpretation software, which was used to characterize more than 50 recombinant serine/threonine kinases, receptor tyrosine kinases, or cytoplasmatic tyrosine kinases

Topics: Poster Abstracts: Bioinfomatics
Publisher: The Association of Biomolecular Resource Facilities
OAI identifier: oai:pubmedcentral.nih.gov:2291825
Provided by: PubMed Central
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