Location of Repository

Selection to minimise noise in living systems and its implications for the evolution of gene expression

By Ben Lehner


Gene expression, like many biological processes, is subject to noise. This noise has been measured on a global scale, but its general importance to the fitness of an organism is unclear. Here, I show that noise in gene expression in yeast has evolved to prevent harmful stochastic variation in the levels of genes that reduce fitness when their expression levels change. Therefore, there has probably been widespread selection to minimise noise in gene expression. Selection to minimise noise, because it results in gene expression that is stable to stochastic variation in cellular components, may also constrain the ability of gene expression to respond to non-stochastic variation. I present evidence that this has indeed been the case in yeast. I therefore conclude that gene expression noise is an important biological trait, and one that probably limits the evolvability of complex living systems

Topics: Report
Publisher: Nature Publishing Group
OAI identifier: oai:pubmedcentral.nih.gov:2290932
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles



    1. (1997). cerevisiae reveals the architecture of biological noise.
    2. (2006). Noise in protein expression scales with natural protein abundance. Nat Genet 38: 636–643 Batada NN, Hurst LD (2007a) Evolution of chromosome organization driven by selection for reduced gene expression noise.
    3. (2006). Nucleic Acids Res 34: D169–D172
    4. This article is licensed under a Creative Commons AttributionNoncommercial-Share Alike 3.0 Licence. Selection to minimise noise

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.