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The multiple sex chromosomes of platypus and echidna are not completely identical and several share homology with the avian Z

By Willem Rens, Patricia CM O'Brien, Frank Grützner, Oliver Clarke, Daria Graphodatskaya, Enkhjargal Tsend-Ayush, Vladimir A Trifonov, Helen Skelton, Mary C Wallis, Steve Johnston, Frederic Veyrunes, Jennifer AM Graves and Malcolm A Ferguson-Smith


A comparative study of the karyotype of the short-beaked echidna shows that monotremes appear to have a unique XY sex chromosome system that shares some homology with the avian Z

Topics: Research
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:2258203
Provided by: PubMed Central
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    1. (2007). A: The delayed rise of present-day mammals.
    2. (1999). An easy and reliable procedure of microdissection technique for the analysis of chromosomal breakpoints and marker chromosomes. Chromosome Res
    3. (1992). Chromosomal composition and position in the echidna meiotic translocation chain.
    4. (2005). Chromosome chains and platypus sex: kinky connections. Bioessays
    5. (1998). CP: A revision of the genus Zaglossus (Monotremata, Tachyglossidae), with description of new species and subspecies.
    6. (1999). DC: Four evolutionary strata on the human X chromosome. Science
    7. (2007). Disruption and pseudoautosomal localization of the major histocompatibility complex in monotremes. Genome Biol
    8. (2002). DW: Comparative mapping of Z-orthologous genes in vertebrates: implications for the evolution of avian sex chromosomes. Cytogenet Genome Res
    9. (2007). Ferguson-Smith AC, Ferguson-Smith MA: The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals.
    10. (1999). Ferguson-Smith MA: Karyotype relationships between four distantly related marsupials revealed by reciprocal chromosome painting. Chromosome Res
    11. (2007). Ferguson-Smith MA: Search for the sexdetermining switch in monotremes:
    12. (2006). FergusonSmith MA: A procedure for image enhancement in chromosome painting. Chromosome Res
    13. (1973). GB: The chromosomes of an egglaying mammal Tachyglossus aculeatus (the echidna). Cytobios
    14. (1998). GC: The platypus is not a rodent: DNA hybridization, amniote phylogeny and the palimpsest theory.
    15. (2006). Graves JA: Assignment of SOX1 to platypus chromosome 20q by fluorescence in situ hybridization. Cytogenet Genome Res
    16. (2005). Graves JA: Autosomal location of genes from the conserved mammalian X in the platypus (Ornithorhynchus anatinus): implications for mammalian sex chromosome evolution. Chromosome Res
    17. (2002). Graves JA: Cloning and mapping of platypus SOX2 and SOX14: insights into SOX group B evolution. Cytogenet Genome Res
    18. (1996). Graves JA: Comparative mapping identifies the fusion point of an ancient mammalian Xautosomal rearrangement. Genomics
    19. (2007). Graves JA: DMRT gene cluster analysis in the platypus: New insights into genomic organization and regulatory regions. Genomics
    20. (2006). Graves JA: How did the platypus get its sex chromosome chain? A comparison of meiotic multiples and sex chromosomes in plants and animals. Chromosoma
    21. (2004). Graves JA: In the platypus a meiotic chain of ten sex chromosomes shares genes with the bird Z and mammal X chromosomes. Nature
    22. (1988). Graves JA: Karyotypic conservation in the mammalian order monotremata (subclass Prototheria). Chromosoma
    23. (1991). Graves JA: Sex chromosome evolution: platypus gene mapping suggests that part of the human X chromosome was originally autosomal. Proc Natl Acad Sci USA
    24. (1998). Graves JA: The origin and loss of the ubiquitin activating enzyme gene on the mammalian Y chromosome. Hum Mol Genet
    25. (2007). Graves JA: The region homologous to the X-chromosome inactivation centre has been disrupted in marsupial and monotreme mammals. Chromosome Res
    26. (2007). Graves JAM: Mapping platypus SOX genes; autosomal location of SOX9 excludes it from sex determining role. Cytogenet Genome Res
    27. (1990). JA: The X chromosome of monotremes shares a highly conserved region with the eutherian and marsupial X chromosomes despite the absence of X chromosome inactivation. Proc Natl Acad Sci USA
    28. (1959). L'expression morphologique de la diagametie chez les sauropsids et les monotremes. Chromosoma
    29. (1949). Les Chromosomes des Vertebrées Lucerne: F Rouge;
    30. (2002). Orthology, paralogy and proposed classification for paralog subtypes. Trends Genet
    31. (2004). Resolution and evolution of the duck-billed platypus karyotype with an X1Y1X2Y2X3Y3X4Y4X5Y5 male sex chromosome constitution. Proc Natl Acad Sci USA
    32. (1999). T: Towards identification of individual homologous chromosomes: comparative genomic hybridization and spectral karyotyping discriminate between paternal and maternal euchromatin in Mus musculus × M. spretus interspecific hybrids. Cytogenet Cell Genet
    33. (1991). The androgen receptor gene is located on a highly conserved region of the X chromosomes of marsupial and monotreme as well as eutherian mammals.
    34. (2006). The Xist RNA gene evolved in eutherians by pseudogenization of a protein-coding gene. Science
    35. (1977). Unique cytogenetic system in monotremes. Chromosoma

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