Skip to main content
Article thumbnail
Location of Repository

Role of the Sympathetic Innervation of the Pacinian Corpuscle

By Joel D. Schiff


An investigation was made into the nature of the role played by the noradrenergic innervation of the pacinian corpuscle. Corpuscles of the cat mesentery and mesocolon were used in all experiments. Blockade of noradrenergic beta receptors by dichloroisoproterenol and interference with norepinephrine release by reserpine are each capable of reversibly blocking mechanoelectric transduction by the pacinian corpuscle. The monoamine oxidase inhibitors iproniazid and phenelzine are capable of protecting the transducer from the blocking effects of reserpine. It is concluded that the presence of norepinephrine, as maintained by sympathetic tonus, is required for the afferent nerve terminal of the pacinian corpuscle to be mechanosensitive

Topics: Article
Publisher: The Rockefeller University Press
OAI identifier:
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles


    1. (1962). C-fiber innervation of a mechanoreceptor. Experientia
    2. (1956). Enhancement of activity in a Pacinian corpuscle by sympathomimetic agents.
    3. (1969). Evidence for a sympathetic alpha receptor blocking action of beta receptor blocking agents.
    4. (1966). Monoamine oxidase inhibitors.
    5. (1962). Reserpine and guanethidine action on peripheral stores of catecholamines.
    6. (1967). The accumulation of (H)-noradrenaline in the adrenergic fibres of reserpine-treated mice.
    7. (1958). The action of sympathomimetic amines in animals treated with reserpine.
    8. (1972). The development of a receptor on a foreign nerve fiber in a Pacinian corpuscle. Science (Wash.
    9. (1967). The effect of reserpine upon the synthesis of norepinephrine in the isolated rabbit heart.
    10. (1971). The fine structure of the sympathetic axons within the Pacinian corpuscle. Brain Res.
    11. (1958). The sites for mechanoelectric conversion in a Pacinian corpuscle.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.