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Electrophysiological Studies of the Antrum Muscle Fibers of the Guinea Pig Stomach

By H. Kuriyama, T. Osa and H. Tasaki


The membrane potentials of single smooth muscle fibers of various regions of the stomach were measured, and do not differ from those measured in intestinal muscle. Spontaneous slow waves with superimposed spikes could be recorded from the longitudinal and circular muscle of the antrum. The development of tension was preceded by spikes but often tension appeared only when the slow waves were generated. Contracture in high K solution developed at a critical membrane potential of -42 mv. MnCl2 blocked the spike generation, then lowered the amplitude of the slow wave. On the other hand, withdrawal of Na+, or addition of atropine and tetrodotoxin inhibited the generation of most of the slow waves but a spike could still be elicited by electrical stimulation. Prostigmine enhanced and prolonged the slow wave; acetylcholine depolarized the membrane without change in the frequency of the slow waves. Chronaxie for the spike generation in the longitudinal muscle of the antrum was 30 msec and conduction velocity was 1.2 cm/sec. The time constant of the foot of the propagated spike was 28 msec. The space constants measured from the longitudinal and circular muscles of the antrum were 1.1 mm and 1.4 mm, respectively

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    1. (1966). a. Electrical responses of smooth muscle to external stimulation in hypertonic solution.
    2. (1967). a. Membrane properties of the smooth muscle of guinea-pig ureter.
    3. (1923). Action currents from the stomach.
    4. (1922). Action currents in stomach and intestine.
    5. (1967). b. Electrophysiological study of intestinal smooth muscle of guinea-pig.
    6. (1966). b. Membrane capacity and resistance in mammalian smooth muscle, o r.
    7. (1967). c. Nervous factors influencing the membrane activity of intestinal smooth muscle.
    8. (1961). Contraction of smooth muscle in nonionic solution.
    9. (1963). Die Doppelsaccharosetrenn Wandtechnik;
    10. (1966). Effects of tetrodotoxin on smooth muscle cells of the guinea pig taenia coli.
    11. (1938). Electric stimulation and conduction of excitation in smooth muscle.
    12. (1962). Electrical activity in intestinal smooth muscle.
    13. (1956). Electrophysiologie der He~muskelfaser. Hans Huber,
    14. (1961). Electrotonus in smooth muscle.
    15. (1958). Excitation and conduction in smooth muscle of isolated taenia coli of the guinea pig.
    16. (1966). Grouped discharges in ureter muscle.
    17. (1958). Membrane potentials recorded with high-resistance microelectrodes; and the effects of changes in ionic environment on the electrical and mechanical activity of the smooth muscle of the taenia coli of the guinea pig.
    18. (1955). Monophasic and diphasic action potentials of the stomach.
    19. (1967). Properties of the inhibitory potential of smooth muscle as observed in the response to field stimulation of the guinea pig taenia coll.
    20. (1966). Tetrodotoxin and manganese ions; effect of electrical activity and tension in taenia coli of guinea pig.
    21. (1942). The action potentials accompanying conducted responses in visceral smooth muscle.
    22. (1945). The action potentials of the stomach.
    23. (1962). The effect of Ca'-on plateau type action potentials in smooth muscle,
    24. (1965). The electrical and contractile activity of the pyloric region in dog and the effects of drugs.
    25. (1965). The responses of single smooth muscle cells of guinea pig taenia coli to intracellularly applied currents, and their effect on the spontaneous electrical activity.
    26. (1968). Two component slow waves in smooth muscle of cat stomach.

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