Stilboestrol toxicity in a dog

Abstract

A case of stilboestrol toxicity is described in a dog which was treated for prostatic hyperplasia with stilboestrol dipropionate (10 mg) daily for 5 days. An initial anaemia and thrombocytopaenia of 19,500/μl was recorded on day 11, and a severe leukocytosis of 125,300/μl on day 15 was followed by a precipitous drop to 8,400/μl on day 21. The dog received antibiotic treatment for concurrent peritonitis and prostatitis/cystitis between days 7 and 15. The dog died on day 41 with marrow aplasia