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The pathogenesis of Acanthamoeba infections: current status\ud and future implications

By Naveed Ahmed Khan

Abstract

Acanthamoeba are opportunistic protozoan parasites that can cause painful, visionthreatening\ud keratitis. However the pathogenesis and pathophysiology of\ud Acanthamoeba keratitis remain incompletely understood. Most cases of\ud Acanthamoeba keratitis develop as a result of poor hygiene in contact lens care but it\ud is unclear how amoebae transmigrate from the environment into the cornea leading to\ud inflammation, photophobia and blindness. Acanthamoeba keratitis has become\ud increasingly important in the past few decades due to increasing populations of\ud contact lens users. The mechanisms associated with the pathogenesis of\ud Acanthamoeba are highly complex, depending on the virulence properties of the\ud parasite, host susceptibility and the environmental conditions. Complete\ud understanding of Acanthamoeba pathogenesis and its associated risks factors should\ud allow us to design strategies for disease prevention and for the rational development\ud of therapeutic interventions against these devastating infections.\ud Acanthamoeba keratitis has become a significant problem in recent years,\ud especially in contact lens wearers exposed to contaminated water

Topics: bcs
Publisher: Eyetext
Year: 2004
OAI identifier: oai:eprints.bbk.ac.uk.oai2:205

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